Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands.
BMC Genomics. 2010 Mar 16;11:177. doi: 10.1186/1471-2164-11-177.
The superfamily of ABC proteins is among the largest known in nature. Its members are mainly, but not exclusively, involved in the transport of a broad range of substrates across biological membranes. Many contribute to multidrug resistance in microbial pathogens and cancer cells. The diversity of ABC proteins in fungi is comparable with those in multicellular animals, but so far fungal ABC proteins have barely been studied.
We performed a phylogenetic analysis of the ABC proteins extracted from the genomes of 27 fungal species from 18 orders representing 5 fungal phyla thereby covering the most important groups. Our analysis demonstrated that some of the subfamilies of ABC proteins remained highly conserved in fungi, while others have undergone a remarkable group-specific diversification. Members of the various fungal phyla also differed significantly in the number of ABC proteins found in their genomes, which is especially reduced in the yeast S. cerevisiae and S. pombe.
Data obtained during our analysis should contribute to a better understanding of the diversity of the fungal ABC proteins and provide important clues about their possible biological functions.
ABC 蛋白超家族是自然界中已知的最大超家族之一。其成员主要（但并非专门）参与跨生物膜运输广泛的底物。许多成员有助于微生物病原体和癌细胞的多药耐药性。真菌中的 ABC 蛋白多样性与多细胞动物中的 ABC 蛋白相当，但迄今为止，真菌 ABC 蛋白几乎没有得到研究。
我们对从代表 5 个真菌门的 18 个目中的 27 个真菌物种的基因组中提取的 ABC 蛋白进行了系统发育分析，从而涵盖了最重要的群组。我们的分析表明，一些 ABC 蛋白亚家族在真菌中保持高度保守，而其他亚家族则经历了显著的群组特异性多样化。不同真菌门的成员在其基因组中发现的 ABC 蛋白数量也存在显著差异，这在酵母 S. cerevisiae 和 S. pombe 中尤为明显减少。
我们分析过程中获得的数据应有助于更好地理解真菌 ABC 蛋白的多样性，并为其可能的生物学功能提供重要线索。
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