麻醉性镇痛药对豚鼠回肠的作用机制。
The mechanism of action of narcotic analgesics in the guinea-pig ileum.
作者信息
North R A, Tonini M
出版信息
Br J Pharmacol. 1977 Dec;61(4):541-9. doi: 10.1111/j.1476-5381.1977.tb07546.x.
Abstract
- Intracellular recordings were made from neurones in the myenteric plexus of the guinea-pig ileum. Single myenteric ganglia were maintained in vitro and drugs were applied by adding them to the perfusing solution. 2. Narcotic analgesics hyperpolarized the membrane of a proportion of neurones in the myenteric plexus. 3. The membrane hyperpolarization was sometimes associated with a decrease in input resistance. These effects reduced the excitability of myenteric neurones. 4. The effects of narcotics occurred at low concentrations (10 nM to 1 micrometer), were stereospecific and were reversed by naloxone. 5. It is proposed that the morphine-sensitive neurones may be the cholinergic efferents to the muscle layers. By hyperpolarizing these neurones, morphine may prevent their excitation by electric field stimulation. This may explain why narcotic analgesics reduce the output of acetylcholine and the contractile response of this preparation when it is excited by field stimulation.
摘要
- 从豚鼠回肠肌间神经丛的神经元进行细胞内记录。将单个肌间神经节维持在体外，并通过将药物添加到灌注溶液中来施加药物。2. 麻醉性镇痛药使肌间神经丛中一部分神经元的膜发生超极化。3. 膜超极化有时与输入电阻降低有关。这些效应降低了肌间神经元的兴奋性。4. 麻醉药在低浓度（10 nM至1微米）时产生效应，具有立体特异性，且可被纳洛酮逆转。5. 有人提出，对吗啡敏感的神经元可能是向肌肉层发出的胆碱能传出神经元。通过使这些神经元超极化，吗啡可能会阻止它们受到电场刺激的兴奋。这可以解释为什么麻醉性镇痛药在该制剂受到电场刺激而兴奋时会减少乙酰胆碱的释放和收缩反应。
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