Yeniad Baris, Canturk Serife, Esin Ozdemir Fatma, Alparslan Nilufer, Akarcay Koray
Istanbul University, Department of Ophthalmology, Turkey.
Cutan Ocul Toxicol. 2010 Jun;29(2):105-9. doi: 10.3109/15569521003631752.
To describe 8 cases of toxic keratopathy due to abuse of topical anesthetic drugs.
Clinical findings from patients with toxic keratopathy were investigated retrospectively.
Two patients had toxic keratopathy bilaterally. Five of 8 patients had an ocular history of a corneal foreign body, 1 had basal membrane dystrophy, 1 had ultraviolet radiation, and 1 had chemical burn. All patients had undergone psychiatric consultation. Four patients had anxiety disorder and 1 had bipolar disease. Clinical signs were improved in all patients with discontinuation of topical anesthetic drug use along with adjunctive psychiatric treatment. Penetrating keratoplasty was performed in 2 patients.
Toxic keratopathy due to topical anesthetic abuse is a curable disease. Early diagnosis and prevention of topical anesthetic drug use are the most important steps in the treatment of this condition. As these patients commonly exhibit psychiatric disorders, adjunctive psychiatric treatment may help to break the chemical addiction.
描述8例因滥用局部麻醉药导致的中毒性角膜病变。
对中毒性角膜病变患者的临床资料进行回顾性研究。
2例患者双侧发生中毒性角膜病变。8例患者中，5例有角膜异物眼病史，1例有基底膜营养不良，1例有紫外线辐射伤，1例有化学烧伤。所有患者均接受过精神科会诊。4例患者患有焦虑症，1例患有双相情感障碍。所有患者停用局部麻醉药并辅以精神科治疗后，临床症状均有改善。2例患者接受了穿透性角膜移植术。
局部麻醉药滥用导致的中毒性角膜病变是一种可治愈的疾病。早期诊断和预防局部麻醉药的使用是治疗该病的最重要步骤。由于这些患者常伴有精神障碍，辅助精神科治疗可能有助于戒除化学成瘾。
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