Department of Urology and Nephrology, Hospital Clinic i Provincial, Barcelona, Spain.
Clin Transplant. 2010 Mar-Apr;24(2):149-56. doi: 10.1111/j.1399-0012.2010.01232.x. Epub 2010 Mar 4.
Mammalian target of rapamycin inhibitor use is associated with numerous adverse events, including dermatologic and mucosal problems. Awareness of these complications, which clinically manifest across a severity spectrum from minor through severe and may occur at varied time points after initiation of sirolimus therapy, can be useful to clinicians in both managing these events and determining the appropriate intervention(s) for patients. This manuscript examines the dermatologic and mucosal problems associated with mammalian target of rapamycin inhibitor use, reviews the literature, and provides personal experiences regarding the management and treatment of these adverse events.
雷帕霉素靶蛋白抑制剂的使用与许多不良反应有关，包括皮肤和黏膜问题。了解这些并发症，这些并发症在临床上表现为从轻微到严重的严重程度谱，并且可能在开始使用西罗莫司治疗后的不同时间点发生，这对临床医生管理这些事件并确定患者的适当干预措施都很有用。本文检查了与雷帕霉素靶蛋白抑制剂使用相关的皮肤和黏膜问题，回顾了文献，并提供了关于这些不良反应的管理和治疗的个人经验。
