Arthritis Res Ther. 2010;12(1):108. doi: 10.1186/ar2919. Epub 2010 Feb 24.
During pregnancy, most patients with rheumatoid arthritis (RA) experience spontaneous improvement of their disease activity. Among the soluble candidates that have been investigated in search for the most relevant disease-remitting factor are the galactosylation levels of immunoglobulin G (IgG). In RA, a higher percentage of IgG lacking the terminal galactose residues, thought to play a pro-inflammatory role, is found. During pregnancy, however, IgG galactosylation levels increase and correlate with improved disease activity. The question remains whether the increase in IgG galactosylation during pregnancy is a mere epiphenomenon or a true remission-inducing factor.
在妊娠期间,大多数类风湿关节炎(RA)患者的疾病活动会自发改善。在寻找最相关的疾病缓解因素的可溶性候选物中,研究了免疫球蛋白 G(IgG)的半乳糖基化水平。在 RA 中,发现具有更高比例的缺乏末端半乳糖残基的 IgG,这些残基被认为具有促炎作用。然而,在妊娠期间,IgG 的半乳糖基化水平增加,并与改善的疾病活动相关。问题仍然是妊娠期间 IgG 半乳糖基化水平的增加是一种单纯的表象还是真正的诱导缓解因素。