辅助雌激素疗法并不能改善绝经后类风湿关节炎患者的疾病活动度。
Adjuvant oestrogen therapy does not improve disease activity in postmenopausal patients with rheumatoid arthritis.
作者信息
van den Brink H R, van Everdingen A A, van Wijk M J, Jacobs J W, Bijlsma J W
机构信息
Department of Rheumatology, University Hospital Utrecht, The Netherlands.
出版信息
Ann Rheum Dis. 1993 Dec;52(12):862-5. doi: 10.1136/ard.52.12.862.
Abstract
OBJECTIVE
To investigate whether oestrogens can be used as treatment to diminish disease activity in women with rheumatoid arthritis.
METHODS
Forty postmenopausal female patients with active rheumatoid arthritis participated in a placebo-controlled, double-blind study on the possible beneficial effect of adjuvant treatment of oestradiol on disease activity.
RESULTS
Thirty three patients completed 52 weeks of treatment with 2 mg oestradiol-valerate or placebo. No statistically significant difference was found in and between both treatment groups with regard to articular indices, pain score by visual analogue scale, erythrocyte sedimentation rate and health questionnaire on daily activities before, during and at the end of the study.
CONCLUSION
This first randomised prospective placebo-controlled study shows no beneficial effect of oestrogens on disease activity in postmenopausal female patients with rheumatoid arthritis.
摘要
目的
研究雌激素是否可用于减轻类风湿关节炎女性患者的疾病活动度。
方法
40名患有活动性类风湿关节炎的绝经后女性患者参与了一项关于雌二醇辅助治疗对疾病活动度可能有益作用的安慰剂对照双盲研究。
结果
33名患者完成了为期52周的2mg戊酸雌二醇或安慰剂治疗。在研究前、研究期间和研究结束时，两个治疗组在关节指数、视觉模拟评分法疼痛评分、红细胞沉降率和日常活动健康问卷方面均未发现统计学上的显著差异。
结论
这项首次随机前瞻性安慰剂对照研究表明，雌激素对绝经后类风湿关节炎女性患者的疾病活动度没有有益作用。
相似文献
1
Adjuvant oestrogen therapy does not improve disease activity in postmenopausal patients with rheumatoid arthritis.辅助雌激素疗法并不能改善绝经后类风湿关节炎患者的疾病活动度。
Ann Rheum Dis. 1993 Dec;52(12):862-5. doi: 10.1136/ard.52.12.862.
2
A randomised controlled trial of the effect of hormone replacement therapy on disease activity in postmenopausal rheumatoid arthritis.一项关于激素替代疗法对绝经后类风湿关节炎疾病活动影响的随机对照试验。
Ann Rheum Dis. 1994 Feb;53(2):112-6. doi: 10.1136/ard.53.2.112.
3
Androgens as adjuvant treatment in postmenopausal female patients with rheumatoid arthritis.雄激素作为绝经后类风湿关节炎女性患者的辅助治疗手段。
Ann Rheum Dis. 1996 Nov;55(11):811-5. doi: 10.1136/ard.55.11.811.
4
Adjuvant oestrogen treatment increases bone mineral density in postmenopausal women with rheumatoid arthritis.辅助雌激素治疗可提高绝经后类风湿关节炎女性的骨密度。
Ann Rheum Dis. 1993 Apr;52(4):302-5. doi: 10.1136/ard.52.4.302.
5
A randomized controlled trial of homeopathy in rheumatoid arthritis.
Rheumatology (Oxford). 2001 Sep;40(9):1052-5. doi: 10.1093/rheumatology/40.9.1052.
6
Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group.米诺环素治疗类风湿性关节炎。一项为期48周的双盲、安慰剂对照试验。MIRA试验组。
Ann Intern Med. 1995 Jan 15;122(2):81-9. doi: 10.7326/0003-4819-122-2-199501150-00001.
7
The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression.在未使用甲氨蝶呤且预后因素较差的早期类风湿性关节炎患者中开展的第一项关于赛妥珠单抗聚乙二醇化修饰物的双盲、随机、平行组研究——C-OPERA研究，显示出对影像学进展的抑制作用。
Ann Rheum Dis. 2016 Jan;75(1):75-83. doi: 10.1136/annrheumdis-2015-207511. Epub 2015 Jul 2.
8
Peroxisome proliferator-activated receptor γ agonist effect on rheumatoid arthritis: a randomized controlled trial.过氧化物酶体增殖物激活受体 γ 激动剂对类风湿关节炎的作用：一项随机对照试验。
Arthritis Res Ther. 2013;15(5):R110. doi: 10.1186/ar4290.
9
LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study.LY2439821，一种人源化抗白细胞介素-17单克隆抗体，用于治疗类风湿性关节炎患者：一项I期随机、双盲、安慰剂对照的概念验证研究。
Arthritis Rheum. 2010 Apr;62(4):929-39. doi: 10.1002/art.27334.
10
The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial.槲皮素对类风湿关节炎女性患者炎症因子及临床症状的影响：一项双盲随机对照试验
J Am Coll Nutr. 2017 Jan;36(1):9-15. doi: 10.1080/07315724.2016.1140093. Epub 2016 Oct 6.
引用本文的文献
1
What is the impact of sex hormones on the pathogenesis of rheumatoid arthritis?性激素对类风湿关节炎发病机制有何影响？
Front Med (Lausanne). 2022 Jul 22;9:909879. doi: 10.3389/fmed.2022.909879. eCollection 2022.
2
Molecular Mechanisms of Sex-Related Differences in Arthritis and Associated Pain.关节炎及相关疼痛的性别差异的分子机制。
Int J Mol Sci. 2020 Oct 26;21(21):7938. doi: 10.3390/ijms21217938.
3
The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis.总雌激素受体α和软骨特异性雌激素受体α表达在雌激素治疗对关节炎的改善作用中的作用。
Arthritis Res Ther. 2014 Jul 15;16(4):R150. doi: 10.1186/ar4612.
4
Oestrogen deficiency modulates particle-induced osteolysis.雌激素缺乏可调节颗粒诱导的骨溶解。
Arthritis Res Ther. 2011 Jun 22;13(3):R100. doi: 10.1186/ar3381.
5
Sexual dimorphism of RA manifestations: genes, hormones and behavior.类风湿关节炎表现的性别二态性：基因、激素与行为。
Nat Rev Rheumatol. 2011 May;7(5):307-10. doi: 10.1038/nrrheum.2010.231. Epub 2011 Feb 1.
6
Postmenopausal hormone therapy: an Endocrine Society scientific statement.绝经后激素治疗：内分泌学会科学声明。
J Clin Endocrinol Metab. 2010 Jul;95(7 Suppl 1):s1-s66. doi: 10.1210/jc.2009-2509. Epub 2010 Jun 21.
7
Is IgG galactosylation the relevant factor for pregnancy-induced remission of rheumatoid arthritis?IgG 半乳糖基化是否是妊娠诱导类风湿关节炎缓解的相关因素？
Arthritis Res Ther. 2010;12(1):108. doi: 10.1186/ar2919. Epub 2010 Feb 24.
8
Effects of postmenopausal hormone therapy on rheumatoid arthritis: the women's health initiative randomized controlled trials.绝经后激素治疗对类风湿关节炎的影响：妇女健康倡议随机对照试验
Arthritis Rheum. 2008 Mar 15;59(3):302-10. doi: 10.1002/art.23325.
9
Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1.类风湿关节炎中的激素替代疗法与较低的可溶性白细胞介素-6受体血清水平及较高的胰岛素样生长因子1相关。
Arthritis Res Ther. 2003;5(4):R202-9. doi: 10.1186/ar761. Epub 2003 May 1.
本文引用的文献
1
NORETHYNODREL WITH MESTRANOL IN TREATMENT OF RHEUMATOID ARTHRITIS.炔诺酮与炔雌醇甲醚治疗类风湿关节炎
JAMA. 1964 Oct 19;190:235. doi: 10.1001/jama.1964.03070160059013.
2
Adjuvant oestrogen treatment increases bone mineral density in postmenopausal women with rheumatoid arthritis.辅助雌激素治疗可提高绝经后类风湿关节炎女性的骨密度。
Ann Rheum Dis. 1993 Apr;52(4):302-5. doi: 10.1136/ard.52.4.302.
3
Interpretation and power of a pooled index.合并指数的解释与功效
J Rheumatol. 1993 Mar;20(3):575-8.
4
Evaluation of the Thompson articular index.
J Rheumatol. 1993 Jan;20(1):28-32.
5
The epidemiology of rheumatoid arthritis in Rochester, Minnesota: a study of incidence, prevalence, and mortality.明尼苏达州罗切斯特市类风湿关节炎的流行病学：发病率、患病率及死亡率研究
Am J Epidemiol. 1980 Jan;111(1):87-98. doi: 10.1093/oxfordjournals.aje.a112878.
6
Relation of menstrual cycle phase to symptoms of rheumatoid arthritis.月经周期阶段与类风湿关节炎症状的关系。
Am J Med. 1983 Jun;74(6):957-60. doi: 10.1016/0002-9343(83)90789-1.
7
8
Female sex hormones suppress development of collagen-induced arthritis in mice.雌性激素可抑制小鼠胶原诱导性关节炎的发展。
Arthritis Rheum. 1986 Dec;29(12):1501-9. doi: 10.1002/art.1780291212.
9
The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.美国风湿病协会1987年修订的类风湿关节炎分类标准。
Arthritis Rheum. 1988 Mar;31(3):315-24. doi: 10.1002/art.1780310302.
10
Effect of oestrogen treatment on clinical and laboratory manifestations of rheumatoid arthritis.雌激素治疗对类风湿关节炎临床及实验室表现的影响。
Ann Rheum Dis. 1987 Oct;46(10):777-9. doi: 10.1136/ard.46.10.777.
Zotero 插件