Deris Z Z, Leow V M, Wan Hassan W M N, Nik Lah N A Z, Lee S Y, Siti Hawa H, Siti Asma H, Ravichandran M
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
Trop Biomed. 2009 Dec;26(3):320-5.
Vibrio cholerae infection is mainly caused acute diarrhoea disease. Bacteraemia due to non-O1 V. cholerae is rare and mainly reported in liver cirrhotic patients. We report one case of non-O1 V. cholerae bacteraemia in splenectomised thalassaemic patient who presented with septic shock secondary to abdominal sepsis. She had undergone emergency laporatomy and was managed in the intensive care unit for nine days. She was treated with meropenem and doxycyline and discharged well after fourteen days of admission. The V. cholerae was identified by API 20NE, serotype and polymerase chain reaction showed as non-O1, non-O139 strain. Besides known cholera-like toxin and El Tor hemolysin, with increasing reported cases of V. cholerae bacteraemia, there is possibility of other virulence factors that allow this organism to invade the bloodstream.
霍乱弧菌感染主要引起急性腹泻病。非O1群霍乱弧菌引起的菌血症较为罕见，主要见于肝硬化患者。我们报告1例脾切除的地中海贫血患者发生非O1群霍乱弧菌菌血症，该患者因腹部脓毒症继发感染性休克。她接受了急诊剖腹手术，并在重症监护病房治疗了9天。给予美罗培南和多西环素治疗，入院14天后康复出院。通过API 20NE鉴定为霍乱弧菌，血清型及聚合酶链反应显示为非O1、非O139菌株。除了已知的霍乱样毒素和埃尔托溶血素外，随着非O1群霍乱弧菌菌血症报告病例的增加，可能存在其他毒力因子使该菌能够侵入血流。
