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c-rel激活但v-rel抑制κB位点的转录。

c-rel activates but v-rel suppresses transcription from kappa B sites.

作者信息

Inoue J, Kerr L D, Ransone L J, Bengal E, Hunter T, Verma I M

机构信息

Molecular Biology and Virology Laboratory, Salk Institute, San Diego, CA 92186-5800.

出版信息

Proc Natl Acad Sci U S A. 1991 May 1;88(9):3715-9. doi: 10.1073/pnas.88.9.3715.

DOI:10.1073/pnas.88.9.3715
PMID:2023921
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC51523/
Abstract

We show that the product of the protooncogene c-rel is a constituent of an NF-kappa B-like complex that binds to the kappa B site originally identified in the enhancer of immunoglobulin kappa light chain gene. c-rel protein synthesized in bacteria binds to the kappa B site in a sequence-specific manner. The rel-kappa B complex can be disrupted by incubation with anti-rel antibodies. The rel protein can form oligomers. The c-rel protein can activate transcription from promoters containing kappa B sites; v-rel, on the other hand, suppresses the transcription of genes linked to kappa B sites. Thus, v-rel may interfere with the normal transcriptional machinery of the cell by acting as a dominant negative mutant.

摘要

我们发现原癌基因c-rel的产物是一种类NF-κB复合物的组成成分，该复合物可与最初在免疫球蛋白κ轻链基因增强子中鉴定出的κB位点结合。在细菌中合成的c-rel蛋白以序列特异性方式与κB位点结合。rel-κB复合物可通过与抗rel抗体孵育而被破坏。rel蛋白可形成寡聚体。c-rel蛋白可激活含有κB位点的启动子的转录；另一方面，v-rel则抑制与κB位点相连的基因的转录。因此，v-rel可能通过作为显性负突变体来干扰细胞的正常转录机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/567b678242c5/pnas01059-0218-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/734c2ed188ac/pnas01059-0216-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/9ea3d85b13ef/pnas01059-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/6b2003fea344/pnas01059-0217-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/e87477ace087/pnas01059-0218-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/aaebebd18a24/pnas01059-0218-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/567b678242c5/pnas01059-0218-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/734c2ed188ac/pnas01059-0216-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/9ea3d85b13ef/pnas01059-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/6b2003fea344/pnas01059-0217-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/e87477ace087/pnas01059-0218-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/aaebebd18a24/pnas01059-0218-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e210/51523/567b678242c5/pnas01059-0218-c.jpg

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c-rel activates but v-rel suppresses transcription from kappa B sites.c-rel激活但v-rel抑制κB位点的转录。
Proc Natl Acad Sci U S A. 1991 May 1;88(9):3715-9. doi: 10.1073/pnas.88.9.3715.
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