Kandasamy S B, Hunt W A, Harris A H
Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20814-5145.
Radiat Res. 1991 May;126(2):218-22.
The role of neurotensin in radiation-induced hypothermia was examined. Intracerebroventricular (ICV) administration of neurotensin produced dose-dependent hypothermia. Histamine appears to mediate neurotensin-induced hypothermia because the mast cell stabilizer disodium cromoglycate and antihistamines blocked the hypothermic effects of neurotensin. An ICV pretreatment with neurotensin antibody attenuated neurotensin-induced hypothermia, but did not attenuate radiation-induced hypothermia, suggesting that radiation-induced hypothermia was not mediated by neurotensin.
研究了神经降压素在辐射诱导的体温过低中的作用。脑室内（ICV）注射神经降压素可产生剂量依赖性的体温过低。组胺似乎介导了神经降压素诱导的体温过低，因为肥大细胞稳定剂色甘酸钠和抗组胺药可阻断神经降压素的降温作用。用神经降压素抗体进行脑室内预处理可减弱神经降压素诱导的体温过低，但不能减弱辐射诱导的体温过低，这表明辐射诱导的体温过低不是由神经降压素介导的。
