卡巴胆碱在大鼠脑导水管周围灰质区域的低温作用可能涉及神经降压素。
The hypothermic action of carbachol in the rat brain periaqueductal grey area may involve neurotensin.
作者信息
Griffiths E C, Slater P, Widdowson P S
出版信息
Br J Pharmacol. 1986 Jul;88(3):653-8. doi: 10.1111/j.1476-5381.1986.tb10247.x.
Abstract
Neurotensin (NT) and carbachol both caused hypothermia when injected into the periaqueductal grey area (PAG) of rat brain. Atropine prevented carbachol- but not NT-induced hypothermia. NT-induced hypothermia was unaffected by various neurotransmitter agonists and antagonists in the PAG. Both NT antibodies and thyrotrophin releasing hormone prevented carbachol hypothermia. It is concluded that the hypothermic action of carbachol in the PAG is mediated via endogenous NT.
摘要
将神经降压素（NT）和卡巴胆碱注射到大鼠脑导水管周围灰质区（PAG）时均会引起体温过低。阿托品可预防卡巴胆碱引起的体温过低，但不能预防NT引起的体温过低。PAG中各种神经递质激动剂和拮抗剂均不影响NT引起的体温过低。NT抗体和促甲状腺激素释放激素均可预防卡巴胆碱引起的体温过低。由此得出结论，卡巴胆碱在PAG中的降温作用是通过内源性NT介导的。
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