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血清活性抑制特定猿猴病毒40诱导的移植抗性及其与仓鼠原发性猿猴病毒40肿瘤出现的相关性。

Serum activity inhibiting specific simian virus 40-induced transplantation resistance and its correlation with primary SV40 tumors appearance in hamsters.

作者信息

Volpe E A

出版信息

Experientia. 1978 Jan 15;34(1):113-6. doi: 10.1007/BF01921935.

DOI:10.1007/BF01921935
PMID:202479
Abstract

Using the modified technique of transplantation test, ITR serum activity was found in most (14 out of 21) individual hamster sera obtained during the latent period of primary SV40 carcinogenesis (60 days after virus infection when newborn). On the other hand, as a rule, no ITR activity was observed in the sera of the same hamsters after tumor appearance and during their growth. ITR activity rapidly disappeared from sera of hamsters neonatally infected with SV40 after their successful immunization with the same virus during the latent period. There appears to be a correlation between the presence of ITR serum factor during the latent period and the subsequent primary SV40 tumor appearance in hamsters.

摘要

采用改良的移植试验技术，在原发性SV40致癌潜伏期（新生时病毒感染后60天）获得的大多数（21份中的14份）仓鼠个体血清中发现了ITR血清活性。另一方面，通常在肿瘤出现后及生长期间，同一仓鼠的血清中未观察到ITR活性。在潜伏期用同一病毒成功免疫新生感染SV40的仓鼠后，其血清中的ITR活性迅速消失。仓鼠潜伏期ITR血清因子的存在与随后原发性SV40肿瘤的出现之间似乎存在相关性。

相似文献

1
Serum activity inhibiting specific simian virus 40-induced transplantation resistance and its correlation with primary SV40 tumors appearance in hamsters.血清活性抑制特定猿猴病毒40诱导的移植抗性及其与仓鼠原发性猿猴病毒40肿瘤出现的相关性。
Experientia. 1978 Jan 15;34(1):113-6. doi: 10.1007/BF01921935.
2
In vivo blocking of SV40 virus-induced antitumor resistance by Syrian hamster sera from early stages of primary SV40 carcinogenesis.在原发性SV40致癌早期阶段，用叙利亚仓鼠血清在体内阻断SV40病毒诱导的抗肿瘤抗性。
Neoplasma. 1976;23(4):345-53.
3
Differences in the capacity of simian virus 40 (SV40) tumor antigens on cells, membranes and in soluble form to induce transplantation immunity in hamsters and mice.猿猴病毒40（SV40）肿瘤抗原在细胞、细胞膜上以及可溶性形式下诱导仓鼠和小鼠移植免疫的能力差异。
Int J Cancer. 1978 Sep 15;22(3):315-22. doi: 10.1002/ijc.2910220315.
4
Influence of BCG vaccination on the primary and transplantable hamster tumors induced by SV40 and on the specific SV40 virus-induced antitumor immunity.卡介苗接种对由SV40诱导的原发性和可移植性仓鼠肿瘤以及对特定的SV40病毒诱导的抗肿瘤免疫的影响。
Neoplasma. 1976;23(2):129-36.
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Prevention of SV40 virus oncogenesis in hamsters. II. The effect of thymectomy on induction of tumor resistance by SV40-transformed human cells.仓鼠中SV40病毒致癌作用的预防。II. 胸腺切除对SV40转化的人细胞诱导肿瘤抗性的影响。
J Immunol. 1967 Dec;99(6):1217-20.
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SV40 tumor rejection induced by vesicular stomatitis virus bearing SV40 tumor-specific transplantation antigen (SV40-TSTA). I. Specificity of immunoprotection and effect of enzyme treatment on TSTA activity.携带SV40肿瘤特异性移植抗原（SV40-TSTA）的水泡性口炎病毒诱导的SV40肿瘤排斥反应。I.免疫保护的特异性及酶处理对TSTA活性的影响。
Int J Cancer. 1977 Jul 15;20(1):51-60. doi: 10.1002/ijc.2910200110.
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Induction of simian virus 40 transplantation immunity in hamsters by gel-purified SV40 large T antigen.通过凝胶纯化的猿猴病毒40大T抗原诱导仓鼠产生猿猴病毒40移植免疫。
Immunol Lett. 1988 Jul;18(3):225-9. doi: 10.1016/0165-2478(88)90023-5.
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Oncogenicity in newborn and adult Syrian hamsters of SV40 temperature-sensitive (ts) mutants.SV40温度敏感（ts）突变体在新生和成年叙利亚仓鼠中的致癌性。
Neoplasma. 1979;26(1):49-56.
9
Failure to induce transplantation immunity to an SV40-induced tumour in hamsters immunized with basic proteins of myelin or malignant tissues.在用髓磷脂碱性蛋白或恶性组织免疫的仓鼠中，未能诱导出对SV40诱导肿瘤的移植免疫。
Br J Cancer. 1978 Jul;38(1):151-3. doi: 10.1038/bjc.1978.176.
10
Tumor induction in newborn and adult Syrian hamsters infected with SV40 temperature-sensitive mutants.感染SV40温度敏感突变体的新生和成年叙利亚仓鼠的肿瘤诱导
Intervirology. 1978;10(2):120-4. doi: 10.1159/000148976.

本文引用的文献

1
IMMUNOLOGICAL DETERMINANTS OF ONCOGENESIS IN HAMSTERS INFECTED WITH SV40 VIRUS.感染SV40病毒的仓鼠肿瘤发生的免疫决定因素
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2
PREVENTION OF TUMOUR INDUCTION IN SV 40-INFECTED HAMSTERS.预防SV40感染仓鼠中的肿瘤诱导
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Immunity in the tumor-bearing host and its modification by serum factors.荷瘤宿主的免疫及其血清因子的调节作用。
Cancer. 1974 Oct;34(4 Suppl):suppl:1452-60. doi: 10.1002/1097-0142(197410)34:8+<1452::aid-cncr2820340817>3.0.co;2-j.
4
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5
Cytostatic antibody and SV40 tumour immunity in hamsters.仓鼠中的细胞生长抑制抗体与SV40肿瘤免疫
Nature. 1971 Oct 1;233(5318):321-4. doi: 10.1038/233321a0.
6
Loss of transplantation antigen in primary simian virus 40-induced tumors and their metastases.原发性猿猴病毒40诱导的肿瘤及其转移灶中移植抗原的丧失。
J Natl Cancer Inst. 1966 Apr;36(4):647-55. doi: 10.1093/jnci/36.4.647.
7
Sequential studies of serum blocking activity in rats bearing chemically induced primary bowel tumors.对患有化学诱导原发性肠肿瘤的大鼠血清阻断活性的系列研究。
J Natl Cancer Inst. 1975 Apr;54(4):959-67.
8
Factors interfering with immunological rejection of tumours.干扰肿瘤免疫排斥的因素。
Br Med Bull. 1976 May;32(2):118-23. doi: 10.1093/oxfordjournals.bmb.a071342.
9
In vivo blocking of SV40 virus-induced antitumor resistance by Syrian hamster sera from early stages of primary SV40 carcinogenesis.在原发性SV40致癌早期阶段，用叙利亚仓鼠血清在体内阻断SV40病毒诱导的抗肿瘤抗性。
Neoplasma. 1976;23(4):345-53.
10
[Determination of the antitumor immunity blocking effect of the serum of Syrian hamsters in the early stages of primary carcinogenesis caused by the SV40 virus].[叙利亚仓鼠血清对SV40病毒引起的原发性致癌早期阶段抗肿瘤免疫阻断作用的测定]
Vestn Akad Med Nauk SSSR. 1976(2):26-71.