Deichman G, Kashkina L, Rapp F
Intervirology. 1978;10(2):120-4. doi: 10.1159/000148976.
Newborn and adult Syrian hamsters were injected with wild-type SV40 and its temperature-sensitive (ts) mutants A30, A209, A239, B201 and BC210. Wild-type SV40 and ts B201 were highly oncogenic for newborn but not adult animals; ts A239, ts A30 and ts BC210 also induced tumors in some adult hamsters. Unexpectedly, the number of tumors induced by ts A209 and ts A239 in newborn animals was very low. The number of tumors observed was also low in adults infected with ts A30, ts A239 and ts BC210. The duration of the latent period of tumors induced in adult animals was the same as in the newborns. The data obtained are discussed in connection with the defectiveness of the mutants to induce tumor-specific transplantation antigen activity in hamster cells.
将野生型SV40及其温度敏感(ts)突变体A30、A209、A239、B201和BC210注射到新生和成年叙利亚仓鼠体内。野生型SV40和ts B201对新生动物具有高度致癌性,但对成年动物无致癌性;ts A239、ts A30和ts BC210在一些成年仓鼠中也诱导出肿瘤。出乎意料的是,ts A209和ts A239在新生动物中诱导出的肿瘤数量非常少。在感染ts A30、ts A239和ts BC210的成年动物中观察到的肿瘤数量也很少。成年动物中诱导出的肿瘤潜伏期与新生动物相同。结合突变体在仓鼠细胞中诱导肿瘤特异性移植抗原活性的缺陷对所得数据进行了讨论。