Queener S F, Fujioka H, Nishiyama Y, Furukawa H, Bartlett M S, Smith J W
Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis 46202-5120.
Antimicrob Agents Chemother. 1991 Feb;35(2):377-9. doi: 10.1128/AAC.35.2.377.
Acridone alkaloids isolated from plants of the family Rutaceae have antiplasmodial activity in rodent models of malaria. Because a variety of antimalarial agents have also been shown to have activity against Pneumocystis carinii, we tested six of these alkaloids in an established culture model for P. carinii. Atalaphillinine and glycobismine A inhibited growth of cultured P. carinii at concentrations of 2.7 and 1.7 microM, respectively. This potency of effect is similar to that of chloroquine (3 microM) but somewhat less than that of primaquine (0.4 microM), which was previously evaluated in the same system.
从芸香科植物中分离出的吖啶酮生物碱在疟疾的啮齿动物模型中具有抗疟原虫活性。由于多种抗疟药也已显示出对卡氏肺孢子虫有活性，我们在已建立的卡氏肺孢子虫培养模型中测试了其中六种生物碱。阿塔拉菲林宁和甘氨双吖啶A分别在浓度为2.7微摩尔和1.7微摩尔时抑制培养的卡氏肺孢子虫的生长。这种作用效力与氯喹（3微摩尔）相似，但略低于先前在同一系统中评估的伯氨喹（0.4微摩尔）。
