Basco L K, Mitaku S, Skaltsounis A L, Ravelomanantsoa N, Tillequin F, Koch M, Le Bras J
Laboratoire de Parasitologie, Institut de Médecine et d'Epidémiologie Africaines, Hôpital Bichat-Claude Bernard, Paris, France.
Antimicrob Agents Chemother. 1994 May;38(5):1169-71. doi: 10.1128/AAC.38.5.1169.
The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.
通过同位素半微量试验评估了呋喃并[2,3 - b]喹啉和吖啶酮生物碱对恶性疟原虫的体外活性。呋喃喹啉核中的吡喃环以及吖啶酮核中的2 - O - 吡喃糖苷和2 - 硝基取代基提高了这些化合物的抗疟活性。这些发现为进一步的化学修饰提供了线索。
