慢性腹泻和营养不良患者中贾第虫病的患病率及治疗情况
Prevalence and treatment of giardiasis in chronic diarrhoea and malnutrition.
作者信息
Sullivan P B, Marsh M N, Phillips M B, Dewit O, Neale G, Cevallos A M, Yamson P, Farthing M J
机构信息
Dunn Nutrition Laboratory, University of Cambridge.
出版信息
Arch Dis Child. 1991 Mar;66(3):304-6. doi: 10.1136/adc.66.3.304.
Abstract
To determine the prevalence of giardiasis in Gambian children with chronic diarrhoea and to assess their response to treatment, 31 children with chronic diarrhoea and malnutrition were investigated for giardiasis using a combination of serology (specific antigiardia IgM antibody) and microscopy of faeces and jejunal biopsy specimens. Fourteen of 31 children with chronic diarrhoea had giardiasis compared with only four of 33 healthy age and sex matched control children. Four of 15 malnourished children without diarrhoea were giardia positive. Twenty-three children with chronic diarrhoea were reinvestigated after treatment with metronidazole; giardia was found in 11 of them. These results show that giardia is highly prevalent in children with chronic diarrhoea and malnutrition and that the infection does not respond to standard therapeutic measures.
摘要
为了确定慢性腹泻的冈比亚儿童贾第虫病的患病率，并评估他们对治疗的反应，采用血清学（特异性抗贾第虫IgM抗体）、粪便显微镜检查和空肠活检标本相结合的方法，对31名患有慢性腹泻和营养不良的儿童进行了贾第虫病调查。31名慢性腹泻儿童中有14名患有贾第虫病，而33名年龄和性别匹配的健康对照儿童中只有4名患病。15名无腹泻的营养不良儿童中有4名贾第虫检测呈阳性。23名慢性腹泻儿童在接受甲硝唑治疗后再次接受调查；其中11名儿童仍检测出贾第虫。这些结果表明，贾第虫在患有慢性腹泻和营养不良的儿童中高度流行，并且该感染对标准治疗措施无反应。
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