贾第虫：既是无害共生体，也是致命病原体。
Giardia: both a harmless commensal and a devastating pathogen.
机构信息
University of Texas School of Public Health and Medical School, St. Luke's Episcopal Hospital, Baylor College of Medicine, and Kelsey Research Foundation, Houston, Texas, USA.
出版信息
J Clin Invest. 2013 Jun;123(6):2352-4. doi: 10.1172/JCI69932.
Abstract
The highly prevalent protozoan Giardia lamblia is an enteropathogen that can be asymptomatic in some individuals, while leading to persistent diarrhea and substantial morbidity in others. In this issue of the JCI, Bartelt et al. describe a mouse model of the disease and investigate the contribution of coincident malnutrition with the development of symptomatic infection. This work in part explains how Giardia infection can lead to growth retardation, and may offer insights that guide future therapeutic strategies.
摘要
高度流行的原生动物蓝氏贾第鞭毛虫是一种肠道病原体，在某些个体中可能无症状，而在其他个体中则导致持续腹泻和大量发病。在本期 JCI 中，Bartelt 等人描述了一种疾病的小鼠模型，并研究了并发营养不良对症状性感染发展的贡献。这项工作部分解释了贾第鞭毛虫感染如何导致生长迟缓，并可能为指导未来治疗策略提供见解。
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Persistent G. lamblia impairs growth in a murine malnutrition model.蓝氏贾第鞭毛虫持续感染会损害营养不良模型中小鼠的生长。
J Clin Invest. 2013 Jun;123(6):2672-84. doi: 10.1172/JCI67294.
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Impact of protein malnutrition on histological parameters of experimentally infected animals with Giardia lamblia.蛋白质营养不良对蓝氏贾第鞭毛虫感染动物组织学参数的影响。
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Preliminary experiments on use of zebrafish as a laboratory model for Giardia duodenalis infection.关于使用斑马鱼作为十二指肠贾第虫感染实验室模型的初步实验。
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Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study.急性贾第虫病 3 年后出现肠易激综合征和慢性疲劳：历史队列研究。
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