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猿猴病毒40与人类乳头多瘤空泡病毒BK碱基序列同源性的电子显微镜研究

Electron microscope study of the base sequence homology between simian virus 40 and human papovavirus BK.

作者信息

Newell N, Lai C J, Khoury G, Kelly T J

出版信息

J Virol. 1978 Jan;25(1):193-201. doi: 10.1128/JVI.25.1.193-201.1978.

DOI:10.1128/JVI.25.1.193-201.1978
PMID:202735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC353916/
Abstract

The base sequence homology between the genomes of simian virus 40 (SV40) and human papovavirus BK (BKV) was studied by the heteroduplex method of Ferguson and Davis (J. Mol. Biol. 94:135-149, 1975). When mounted for microscopy in 30% formamide (Tm-35 degrees C), BKV/SV40 heteroduplexes were an average of 92% double-stranded and contained only two small nonhomologous regions that mapped near the junctions between the early and late regions of the SV40 Genome. At higher formamide concentrations, the fraction of duplex DNA in the BKV/SV40 heteroduplexes decreased, indicating significant base mismatching in the homologous regions. The strongest regions of homology were located in the late region.

摘要

通过弗格森和戴维斯的异源双链法（《分子生物学杂志》94:135 - 149，1975年）研究了猴病毒40（SV40）和人乳头多瘤病毒BK（BKV）基因组之间的碱基序列同源性。当在30%甲酰胺（熔点温度-35℃）中固定用于显微镜观察时，BKV/SV40异源双链平均92%为双链，仅包含两个小的非同源区域，这些区域位于SV40基因组早期和晚期区域之间的连接处附近。在更高的甲酰胺浓度下，BKV/SV40异源双链中双链DNA的比例降低，表明同源区域存在明显的碱基错配。同源性最强的区域位于晚期区域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7e0/353916/8a1ee8e19856/jvirol00193-0211-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7e0/353916/373daf4cd38c/jvirol00193-0209-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7e0/353916/8a1ee8e19856/jvirol00193-0211-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7e0/353916/373daf4cd38c/jvirol00193-0209-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7e0/353916/8a1ee8e19856/jvirol00193-0211-a.jpg

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本文引用的文献

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Prevalence in England of antibody to human polyomavirus (B.k.).英国人群中人类多瘤病毒（BK）抗体的流行率。
Br Med J. 1973 Jan 13;1(5845):77-8. doi: 10.1136/bmj.1.5845.77.
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THE NUCLEIC ACID OF SIMIAN VIRUS 40.猴病毒40的核酸
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Dependence of the melting temperature of DNA on salt concentration.DNA熔解温度对盐浓度的依赖性。
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The association of viruses with urveal melanoma.病毒与葡萄膜黑色素瘤的关联。
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Viable deletion mutant of human papovavirus BK that induces insulinomas in hamsters.可诱导仓鼠发生胰岛素瘤的人乳头多瘤空泡病毒BK的活缺失突变体。
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Comparative study of papovavirus DNA: BKV(MM), BKV(WT) and SV40.乳头多瘤空泡病毒DNA的比较研究：BK病毒（MM）、BK病毒（野生型）和猿猴空泡病毒40
Nucleic Acids Res. 1979 Oct 10;7(3):651-68. doi: 10.1093/nar/7.3.651.
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Functional similarity between the early antigens of simian virus 40 and human papovavirus BK.猴病毒40早期抗原与人乳头瘤病毒BK之间的功能相似性。
J Virol. 1979 Apr;30(1):141-7. doi: 10.1128/JVI.30.1.141-147.1979.
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Evolutionary relationships of the primate papovaviruses: base sequence homology among the genomes of simian virus 40, stump-tailed macaque virus, and SA12 virus.灵长类乳头多瘤空泡病毒的进化关系：猴病毒40、短尾猕猴病毒和SA12病毒基因组间的碱基序列同源性
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J Mol Biol. 1974 Oct 15;89(1):113-26. doi: 10.1016/0022-2836(74)90165-x.