乳多空病毒、BK病毒和猴病毒40基因组之间的同源性及关系
Homology and relationship between the genomes of papovaviruses, BK virus and simian virus 40.
作者信息
Khoury G, Howley P M, Garon C, Mullarkey M F, Takemoto K K, Martin M A
出版信息
Proc Natl Acad Sci U S A. 1975 Jul;72(7):2563-7. doi: 10.1073/pnas.72.7.2563.
A number of hybridization techniques have been used to assess the homology between the genomes of BK virus (BKV) and simian virus 40 (SV40). A noncontiguous set of homologous sequences has been localized primarily within the late region of the SV40 genome, and these sequences presumably account for the cross-reaction between V-antigens of the two viruses. The reason for the relatively strong crossreaction between SV40 and BKV T-antigens is still unclear. The sequence homology and similarity in genomic organization suggest a close relationship between these papovaviruses.
已使用多种杂交技术来评估BK病毒（BKV）和猴病毒40（SV40）基因组之间的同源性。一组不连续的同源序列主要定位于SV40基因组的晚期区域，这些序列可能是这两种病毒V抗原之间交叉反应的原因。SV40和BKV T抗原之间相对较强交叉反应的原因仍不清楚。基因组组织中的序列同源性和相似性表明这些乳头瘤多瘤空泡病毒之间存在密切关系。
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