Kurabekova R M, Mataradze G D, Rozen V B
Probl Endokrinol (Mosk). 1991 Jan-Feb;37(1):50-2.
A study was made of the role of the adrenal cortex in the formation and modulation of the level of corticosteroid-binding globulin (CBG) in the serum of male and female rats. Corticosteroids were shown to be potent negative regulators of a CBG level in rats, the level of this protein being more sensitive to the action of these hormones in male rats than in females. Adrenalectomy in mature as well as in prepubertal rats did not level down sex differences in the level of CBG. A study of possible interdependent influence of corticosteroids and sex hormones on the level of CBG has shown that adrenocortical hormones produce an independent direct effect of the level of CBG. Producing a negative effect on the level of CBG, corticosteroids are involved in the modulation of sex dimorphism of the level of this protein in rats, enhancing sex differentiation of the CBG level in males and weakening it in female rats.
对肾上腺皮质在雄性和雌性大鼠血清中皮质类固醇结合球蛋白（CBG）水平的形成和调节中的作用进行了研究。结果表明，皮质类固醇是大鼠CBG水平的有效负调节因子，该蛋白水平在雄性大鼠中对这些激素的作用比雌性大鼠更敏感。对成熟大鼠和青春期前大鼠进行肾上腺切除术后，CBG水平的性别差异并未消除。对皮质类固醇和性激素对CBG水平可能的相互影响的研究表明，肾上腺皮质激素对CBG水平产生独立的直接影响。皮质类固醇对CBG水平产生负面影响，参与调节大鼠中该蛋白水平的性别二态性，增强雄性大鼠CBG水平的性别分化，减弱雌性大鼠的性别分化。
