Kurabekova R M, Mataradze G D, Rozen V B
Probl Endokrinol (Mosk). 1988 Nov-Dec;34(6):66-70.
The role of sex steroids was studied at different stages of ontogenesis in the regulation and programming of the level of corticosteroid binding globulin (CBG) in the blood serum of female and male rats. The blood concentration of CBG was shown to be a sex determined feature: its level in female rats was a 2.5-fold higher than that in male rats; sex differences of this function of the liver were preserved in a primary culture of hepatocytes. Androgens (A) in adult animals were shown to decrease the level of CBG, and estrogens (E) did not influence the blood level of this protein. Castration of adult males leading to an increase of the level of CBG by 1.5-fold did not eliminate sex differences. However gonadectomy of males on the first day of the life or in prepubertal period (at the age of 3-4 weeks) resulted in complete "feminization" of the CBG content in these animals at the age of 10-12 weeks. Ovariectomy in female rats in the prepubertal period did not influence the level of CBG in adult female rats. The administration of A to females or castrated males did not prevent the development of a high level of CBG at older age. Irreversible suppression of the level of CBG in adult animals could be artificially induced by the administration of A to gonadectomized female and male rats in the prepubertal period.(ABSTRACT TRUNCATED AT 250 WORDS)
研究了性类固醇在雌性和雄性大鼠个体发育不同阶段对血清中皮质类固醇结合球蛋白（CBG）水平的调节和编程作用。结果表明，CBG的血浓度具有性别决定特征：雌性大鼠的CBG水平比雄性大鼠高2.5倍；这种肝脏功能的性别差异在肝细胞原代培养中得以保留。成年动物中的雄激素（A）可降低CBG水平，而雌激素（E）对该蛋白的血水平无影响。成年雄性大鼠去势后CBG水平升高1.5倍，但并未消除性别差异。然而，在出生第一天或青春期前（3 - 4周龄）对雄性大鼠进行性腺切除，会导致这些动物在10 - 12周龄时CBG含量完全“女性化”。青春期前对雌性大鼠进行卵巢切除，对成年雌性大鼠的CBG水平无影响。给雌性或去势雄性大鼠注射A并不能阻止其在老年时出现高水平的CBG。在青春期前对去势的雌性和雄性大鼠注射A可人为诱导成年动物CBG水平的不可逆抑制。（摘要截选至250字）
