Kurabekova R M, Mataradze G D, Rozen V B
Biull Eksp Biol Med. 1990 Jan;109(1):6-8. doi: 10.1007/BF00839725.
The mechanism of estrogen action on CBG level in blood serum was studied in the experiments on white rats. It was shown that estradiol injection at the dose 100 micrograms for 3 weeks induced the increasing of CBG serum level in intact males, but it was not changed in the gonadectomized males and females. The presence of the positive effect of exogenic estrogens only in the intact males was connected with the estrogen depression of testis function. It suggests the absence of direct positive estrogens action on the level of CBG in the rats. The estrogen effect is not mediated by adrenal corticosteroids, and has independent negative action on CBG level in the rat. Thus, estrogen does not participate in the endocrine regulation of CBG content in the mature rats.
在对白鼠的实验中研究了雌激素对血清中皮质类固醇结合球蛋白（CBG）水平的作用机制。结果表明，以100微克的剂量注射雌二醇，持续3周，可使未阉割雄性大鼠的血清CBG水平升高，但在去势的雄性和雌性大鼠中该水平未发生变化。外源性雌激素仅在未阉割雄性大鼠中产生积极作用，这与雌激素对睾丸功能的抑制有关。这表明雌激素对大鼠CBG水平不存在直接的积极作用。雌激素的作用不是由肾上腺皮质类固醇介导的，且对大鼠CBG水平具有独立的负面作用。因此，雌激素不参与成年大鼠CBG含量的内分泌调节。
