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精神分裂症的长期临床结局,特别提及性别差异

Long-term clinical outcome of schizophrenia with special reference to gender differences.

作者信息

Opjordsmoen S

机构信息

University of Oslo, Gaustad Hospital, Norway.

出版信息

Acta Psychiatr Scand. 1991 Apr;83(4):307-13. doi: 10.1111/j.1600-0447.1991.tb05545.x.

DOI:10.1111/j.1600-0447.1991.tb05545.x
PMID:2028808
Abstract

A sample of 94 first-admitted schizophrenics and 47 patients with schizophreniform disorder (DSM-III) was personally re-examined after a mean of 10 years (by Retterstöl), and 110 of the patients after a mean of 31 years (by the author). Nearly half of the patients were admitted in 1946-1948 (long-term) and the remaining in 1958-1961 (short-term). Average outcome was significantly more favourable for short-term than for long-term patients. Single marital status and no, minimal or mild psychosocial stressor at onset (Axis IV) predicted poor long-term outcome. At 10-year follow-up there was no difference between men and women in clinical outcome. No substantial change was revealed in men at last follow-up, whereas on average women had clearly deteriorated.

摘要

对94例首次入院的精神分裂症患者和47例精神分裂症样障碍患者(DSM-III)进行了复查,平均间隔10年(雷特斯托尔复查),另有110例患者平均间隔31年(作者复查)。近一半患者于1946 - 1948年入院(长期),其余患者于1958 - 1961年入院(短期)。短期患者的平均预后明显优于长期患者。单身婚姻状况以及起病时无、轻微或轻度心理社会应激源(轴IV)预示着长期预后不良。在10年随访中,男女临床预后无差异。在最后一次随访时,男性病情无实质性变化,而女性平均病情明显恶化。

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