Carpiniello Bernardo, Pinna Federica, Tusconi Massimo, Zaccheddu Enrico, Fatteri Francesca
Section of Psychiatry, Department of Public Health, University of Cagliari, Liguria Street 13, 09127 Cagliari, Italy.
Schizophr Res Treatment. 2012;2012:576369. doi: 10.1155/2012/576369. Epub 2012 Jan 16.
The aim of the paper was to evaluate rates of clinical remission and recovery according to gender in a cohort of chronic outpatients attending a university community mental health center who had been diagnosed with schizophrenia and schizoaffective disorder according to DSM-IV-TR. A sample of 100 consecutive outpatients (70 males and 30 females) underwent comprehensive psychiatric evaluation using the Structured Clinical Interview for Diagnosis of Axis I and II DSM-IV (SCID-I and SCID-II, Version R) and an assessment of psychopathology, social functioning, clinical severity, subjective wellbeing, and quality of life, respectively by means of PANSS (Positive and Negative Syndrome Scale), PSP (Personal and Social Performance), CGI-SCH (Clinical Global Impression-Schizophrenia scale), SWN-S (Subjective Well-being under Neuroleptics-scale), and WHOQOL (WHO Quality of Life). Rates of clinical remission and recovery according to different criteria were calculated by gender. Higher rates of clinical remission and recovery were generally observed in females than males, a result consistent with literature data. Overall findings from the paper support the hypothesis of a better outcome of the disorders in women, even in the very long term.
本文旨在评估一所大学社区心理健康中心的慢性门诊患者队列中,根据性别划分的临床缓解率和康复率。该队列中的患者均根据《精神疾病诊断与统计手册》第四版修订版(DSM-IV-TR)被诊断为精神分裂症和分裂情感性障碍。连续抽取100名门诊患者样本(70名男性和30名女性),使用《精神疾病诊断与统计手册》轴I和轴II障碍的结构化临床访谈(SCID-I和SCID-II,R版)进行全面的精神病学评估,并分别通过阳性与阴性症状量表(PANSS)、个人和社会功能量表(PSP)、精神分裂症临床总体印象量表(CGI-SCH)以及抗精神病药物治疗下主观幸福感量表(SWN-S)和世界卫生组织生活质量量表(WHOQOL)对精神病理学、社会功能、临床严重程度、主观幸福感和生活质量进行评估。根据不同标准计算了按性别划分的临床缓解率和康复率。总体而言,女性的临床缓解率和康复率普遍高于男性,这一结果与文献数据一致。本文的总体研究结果支持如下假设:即使从长远来看,女性患者的病情转归也更好。