抗心磷脂抗体介导的补体激活。
Complement activation by anticardiolipin antibodies.
作者信息
Santiago M B, Gaburo N, de Oliveira R M, Cossermelli W
机构信息
Laboratory of Investigation in Rheumatology, University of São Paulo, School of Medicine, Brazil.
出版信息
Ann Rheum Dis. 1991 Apr;50(4):249-50. doi: 10.1136/ard.50.4.249.
A haemolytic assay was used to test the complement fixation ability of 16 serum samples with high concentrations of anti-cardiolipin antibodies. Fourteen patients had clinical complications usually associated with these antibodies--namely, recurrent abortions, thrombosis, or thrombocytopenia. Complement fixation by anticardiolipin antibodies was shown in only four of these patients and was not directly related to the antibody concentration. Because anticardiolipin antibodies in most of these patients did not activate the complement pathway it is unlikely that the complement cascade has an important role in the clinical complications associated with these antibodies.
采用溶血试验检测了16份高浓度抗心磷脂抗体血清样本的补体结合能力。14名患者出现了通常与这些抗体相关的临床并发症，即反复流产、血栓形成或血小板减少症。在这些患者中，仅4名患者的抗心磷脂抗体表现出补体结合能力，且这与抗体浓度无直接关系。由于这些患者中的大多数抗心磷脂抗体未激活补体途径，因此补体级联反应在与这些抗体相关的临床并发症中不太可能起重要作用。
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