Harris E N, Gharavi A E, Boey M L, Patel B M, Mackworth-Young C G, Loizou S, Hughes G R
Lancet. 1983 Nov 26;2(8361):1211-4. doi: 10.1016/s0140-6736(83)91267-9.
A new solid-phase radioimmunoassay for the detection of anticardiolipin antibodies is 200-400 times more sensitive than the precipitation method used in the Venereal Disease Reference Laboratory test. 61% of serum samples from patients with systemic lupus erythematosus (SLE) had high levels of anticardiolipin antibodies of at least one immunoglobulin class. There were strong correlations between raised anticardiolipin levels and the lupus anticoagulant, venous and arterial thrombosis, and thrombocytopenia, but no correlation with anti-DNA antibody levels. Of the 15 patients with the highest anticardiolipin titres, 6 had a history of venous thrombosis, 5 cerebral thrombosis, 5 thrombocytopenia, and 2 each pulmonary hypertension and multiple abortions. This simple immunoassay appears to have predictive value for thrombosis in SLE and related disorders.
一种用于检测抗心磷脂抗体的新型固相放射免疫测定法，其灵敏度比性病参考实验室检测中使用的沉淀法高200 - 400倍。系统性红斑狼疮（SLE）患者的血清样本中，61%至少有一种免疫球蛋白类别的抗心磷脂抗体水平较高。抗心磷脂水平升高与狼疮抗凝物、静脉和动脉血栓形成以及血小板减少症之间存在强相关性，但与抗DNA抗体水平无关。在抗心磷脂滴度最高的15名患者中，6人有静脉血栓形成病史，5人有脑血栓形成病史，5人有血小板减少症，2人有肺动脉高压和多次流产史。这种简单的免疫测定法似乎对SLE及相关疾病中的血栓形成具有预测价值。
