Maier H, Dietz A, Gewelke U, Heller W D
Univ. HNO-Klinik Heidelberg.
Laryngorhinootologie. 1991 Feb;70(2):93-8. doi: 10.1055/s-2007-997996.
A case-control study of squamous cell carcinoma of the upper aerodigestive tract conducted in Heidelberg and Giessen (FRG) provided information on occupational factors in 200 patients and 800 controls (adjusted to sex, age and area of living; 4:1 matched design). The number of subjects exposed to wood dusts, organic chemicals, coal products or to cement was significantly elevated in the tumour group. An increased risk for head and neck cancer was observed after exposition to wood dust (RR = 2,2), organic compounds (RR = 2,4), coal products (RR = 2,7) and especially to cement (RR = 4,4). The cancer risk due to cement exposition showed a positive correlation to the duration of exposition and remained significantly elevated after adjustment for alcohol and tobacco consumption.
在德国海德堡和吉森开展的一项关于上呼吸道和消化道鳞状细胞癌的病例对照研究，提供了200例患者和800例对照（根据性别、年龄和居住地区进行调整；采用4:1匹配设计）职业因素方面的信息。肿瘤组中接触木屑、有机化学品、煤制品或水泥的受试者数量显著增加。接触木屑（相对危险度=2.2）、有机化合物（相对危险度=2.4）、煤制品（相对危险度=2.7），尤其是水泥（相对危险度=4.4）后，观察到头颈癌风险增加。因接触水泥导致的癌症风险与接触持续时间呈正相关，在对饮酒和吸烟量进行调整后仍显著升高。
