de Brabander J M, de Bruin J P, van Eden C G
Netherlands Institute for Brain Research, Amsterdam.
Behav Brain Res. 1991 Jan 31;42(1):67-75. doi: 10.1016/s0166-4328(05)80041-5.
Performance in food hoarding, a species-typical task, and spatial delayed alternation, a learning task, was investigated in male rats with bilateral medial prefrontal cortex (mPFC) lesions sustained in adulthood or at the age of 6 days. Animals with adult mPFC lesions hoarded significantly fewer food pellets than their controls. The mPFC lesion effect on hoarding behaviour of the neonatally operated rats was unclear because of the unexpectedly low hoarding score of their controls. In the spatial delayed alternation task, the animals with mPFC lesions in adulthood exhibited a permanent deficit, while the animals with neonatal mPFC lesions showed no significant deficits. It is concluded that a bilateral lesion in adulthood, mainly affecting the frontal area 2 and the dorsal anterior cingulate area of the mPFC, results in a permanent deficit in food hoarding and spatial delayed alternation performance, whereas a similarly restricted mPFC lesion at the age of 6 days shows a complete sparing of the spatial delayed alternation task performance.
研究了成年期或6日龄时遭受双侧内侧前额叶皮质（mPFC）损伤的雄性大鼠在食物贮藏（一种物种典型任务）和空间延迟交替（一种学习任务）中的表现。成年期mPFC损伤的动物贮藏的食丸明显少于其对照组。由于其对照组的贮藏分数意外较低，mPFC损伤对新生期手术大鼠贮藏行为的影响尚不清楚。在空间延迟交替任务中，成年期mPFC损伤的动物表现出永久性缺陷，而新生期mPFC损伤的动物则无明显缺陷。得出的结论是，成年期双侧损伤主要影响mPFC的额叶2区和背侧前扣带区，会导致食物贮藏和空间延迟交替表现出现永久性缺陷，而6日龄时类似局限的mPFC损伤则显示空间延迟交替任务表现完全不受影响。
