Carlsson J, Armstrong V W, Reiber H, Felgenhauer K, Seidel D
Department of Clinical Chemistry, University Hospital Göttingen, FRG.
Clin Chim Acta. 1991 Feb 15;196(2-3):167-76. doi: 10.1016/0009-8981(91)90070-s.
Apolipoprotein E was measured in paired sera and cerebrospinal fluid samples from 483 neurological patients. The average apolipoprotein E concentration was 7.5 (+/- 3.1) mg/l in cerebrospinal fluid and 93.5 (+/- 29.7) mg/l in serum. Mean apolipoprotein B concentrations in 88 patients were 0.77 +/- 3.4 mg/l in cerebrospinal fluid and 1.06 +/- 0.31 g/l in serum. The apolipoprotein E concentration in cerebrospinal fluid was much greater than expected for passive diffusion from serum. By contrast to apolipoprotein B, there was no correlation between the apolipoprotein E cerebrospinal fluid/serum concentration quotient and the albumin concentration quotient. This suggests that apolipoprotein E in cerebrospinal fluid, unlike apolipoprotein B, is locally synthesized and that the use of a cerebrospinal fluid/serum concentration quotient is unnecessary. In a control group (n = 64) the mean cerebrospinal fluid apolipoprotein E value (+/- SD) was 5.9 (1.6) mg/l. Elevated cerebrospinal fluid apolipoprotein E concentrations were observed in acute (n = 22, 12.5 +/- 6.2 mg/l) and chronic inflammatory central nervous system diseases (n = 15, 10.4 +/- 2.4 mg/l).
对483例神经系统疾病患者的配对血清和脑脊液样本进行了载脂蛋白E检测。脑脊液中载脂蛋白E的平均浓度为7.5（±3.1）mg/l，血清中为93.5（±29.7）mg/l。88例患者脑脊液中载脂蛋白B的平均浓度为0.77±3.4mg/l，血清中为1.06±0.31g/l。脑脊液中载脂蛋白E的浓度远高于从血清被动扩散所预期的浓度。与载脂蛋白B不同，载脂蛋白E脑脊液/血清浓度商与白蛋白浓度商之间没有相关性。这表明脑脊液中的载脂蛋白E与载脂蛋白B不同，是局部合成的，因此无需使用脑脊液/血清浓度商。在一个对照组（n = 64）中，脑脊液载脂蛋白E的平均数值（±标准差）为5.9（1.6）mg/l。在急性（n = 22，12.5±6.2mg/l）和慢性炎症性中枢神经系统疾病（n = 15，10.4±2.4mg/l）患者中观察到脑脊液载脂蛋白E浓度升高。
