Torrens M, San L, Peri J M, Olle J M
Section of Drug Addiction, Hospital del Mar, Autonomous University of Barcelona, Spain.
Drug Alcohol Depend. 1991 Jan;27(1):29-34. doi: 10.1016/0376-8716(91)90083-b.
Abuse of cocaine is becoming a major problem among heroin addicts in Spain. Between 1987 and 1988, 75% of patients admitted as inpatients for detoxification from opiate dependence had consumed cocaine during the 6 months prior to admission and 25% had abused cocaine daily or several times/week. These cocaine abusers showed more toxicologic and psychopathologic problems than opiate addicts who did not abuse cocaine. The opiate addicts who also abused cocaine had begun using illicit drugs earlier and showed a higher frequency of anti-HIV antibodies. They also had more antisocial personality disorders and persistence of depressive symptoms during opiate detoxification than heroin addicts who did not abuse cocaine. Based on these findings, we insist on the need to develop different treatments for detoxifying patients with this dual addiction.
在西班牙,可卡因滥用正成为海洛因成瘾者中的一个主要问题。1987年至1988年间,75%因阿片类药物依赖而住院进行戒毒的患者在入院前6个月内使用过可卡因,25%的患者每天或每周多次滥用可卡因。与未滥用可卡因的阿片类成瘾者相比,这些可卡因滥用者表现出更多的毒理学和精神病理学问题。同时滥用可卡因的阿片类成瘾者更早开始使用非法药物,且抗HIV抗体的检出率更高。与未滥用可卡因的海洛因成瘾者相比,他们在阿片类药物戒毒期间还存在更多的反社会人格障碍和抑郁症状持续存在的情况。基于这些发现,我们坚持认为有必要针对这种双重成瘾的患者开发不同的戒毒治疗方法。