Cardiothoracic Section, Department of Surgery, Aga Khan University Hospital, Stadium Road, Karachi, Pakistan.
Diabetol Metab Syndr. 2010 Mar 19;2:17. doi: 10.1186/1758-5996-2-17.
The combination of depression with type 2 diabetes is a public health problem. If diabetes is managed in its initial phase, the morbidity and mortality due to this combination may be prevented at an early stage. Therefore, we aimed to determine the association of depression with newly diagnosed type 2 diabetes among adults aged between 25 to 60 years in Karachi, Pakistan.
From July 2006 to September 2007, a matched case control study (n = 592) was conducted in Civil Hospital, Karachi. Incident cases of type 2 diabetes (n = 296) diagnosed within one month were recruited from diabetic Out Patient Department (OPD) of Civil Hospital, Karachi. They were matched on age and sex with controls (n = 296), who were attendants sitting in the medical out patient department of the same hospital, recruited on the basis of absence of classical symptoms of polyuria and polydipsia along with random blood glucose level of <200 mg/dl measured by a glucometer. Depression was identified by the Siddiqui Shah Depression Scale. Conditional logistic regression was applied to examine the association of depression and other independent variables with newly diagnosed type 2 diabetes at 95% C.I. and P < 0.05.
The study comprised of 592 subjects with 432(73%) males and 160(27%) females. Depression was significantly associated with newly diagnosed type 2 diabetes having mild level (mOR: 3.86; 95%CI: 2.22,6.71) and moderate to severe level (mOR: 3.41; 95%CI: 2.07,5.61). History of (h/o) gestational diabetes (mOR: 2.83; 95%CI: 1.05,7.64), family h/o diabetes (mOR: 1.59; 95%CI: 1.04,2.43), nuclear family (mOR: 1.75; 95%CI: 1.14,2.69), BMI (mOR: 1.62; 95%CI: 1.01,2.60 for obese and mOR: 2.12; 95%CI: 1.19,3.79 for overweight vs healthy to underweight) were also significantly associated with outcome, adjusting for age, sex, marital status, h/o smoking and h/o high BP.
Diabetics should be screened simultaneously for depression and concomitant preventive strategies for gestational diabetes, nuclear family and high BMI should also be used to prevent mortality/morbidity among patients between 25 to 60 years of age.
抑郁症与 2 型糖尿病并存是一个公共卫生问题。如果在糖尿病的初始阶段进行管理，可能会在早期预防因这种组合而导致的发病率和死亡率。因此，我们旨在确定在巴基斯坦卡拉奇年龄在 25 至 60 岁之间的成年人中，抑郁与新诊断的 2 型糖尿病之间的关联。
2006 年 7 月至 2007 年 9 月，在卡拉奇民事医院进行了一项匹配病例对照研究（n=592）。在卡拉奇民事医院糖尿病门诊（n=296）中，在一个月内确诊的 2 型糖尿病新发病例被招募为病例。他们按年龄和性别与对照组（n=296）相匹配，对照组为在同一医院的医疗门诊就诊的患者，他们没有多尿和多饮的典型症状，并且随机血糖水平<200mg/dl 通过血糖仪测量。使用 Siddiqui Shah 抑郁量表确定抑郁。应用条件逻辑回归检验抑郁和其他独立变量与新诊断的 2 型糖尿病之间的关联，并在 95%置信区间（CI）和 P<0.05 下进行分析。
该研究共纳入 592 名受试者，其中 432 名（73%）为男性，160 名（27%）为女性。患有轻度抑郁（mOR：3.86；95%CI：2.22，6.71）和中重度抑郁（mOR：3.41；95%CI：2.07，5.61）的患者与新诊断的 2 型糖尿病显著相关。有（h/o）妊娠糖尿病史（mOR：2.83；95%CI：1.05，7.64）、家族糖尿病史（mOR：1.59；95%CI：1.04，2.43）、核心家庭（mOR：1.75；95%CI：1.14，2.69）、BMI（mOR：1.62；95%CI：1.01，2.60 为肥胖，mOR：2.12；95%CI：1.19，3.79 为超重与健康至消瘦）与结局显著相关，调整年龄、性别、婚姻状况、吸烟史和高血压史后。
应同时对糖尿病患者进行抑郁筛查，同时应采取预防妊娠糖尿病、核心家庭和高 BMI 的综合策略，以预防 25 至 60 岁患者的死亡率/发病率。
