Department of Anaesthesiology, Narayana Hrudayalaya Institute of Medical Sciences, Bommasandra Industrial Area, Bangalore, India.
Eur J Anaesthesiol. 2010 Nov;27(11):973-7. doi: 10.1097/EJA.0b013e3283383506.
Coronary artery bypass graft surgery in high-risk patients may be associated with postoperative renal dysfunction. N-Acetylcysteine is a powerful antioxidant and has been used to prevent contrast-induced renal dysfunction. The efficacy of N-acetylcysteine in preventing postoperative renal dysfunction following off-pump coronary artery bypass graft surgery was studied.
A prospective, randomized, controlled study was conducted in patients undergoing off-pump coronary artery bypass graft. The study group (37 patients) received N-acetylcysteine in the perioperative period, whereas the control group (37 patients) did not. The data obtained were analysed using the independent sample t-test (Student's t-test) and χ-test.
There was no significant difference in the incidence of renal dysfunction between the two groups. Three patients (8.6%) in the N-acetylcysteine group and four (11.4%) in the control group developed renal dysfunction (P value was 1.00).
N-Acetylcysteine does not have any beneficial effect on renal function in high-risk patients undergoing off-pump coronary artery bypass graft.
高危患者行冠状动脉旁路移植术可能与术后肾功能障碍相关。N-乙酰半胱氨酸是一种强大的抗氧化剂，已被用于预防对比剂诱导的肾功能障碍。本研究旨在探讨 N-乙酰半胱氨酸预防不停跳冠状动脉旁路移植术后肾功能障碍的疗效。
对行不停跳冠状动脉旁路移植术的患者进行前瞻性、随机、对照研究。研究组（37 例）在围手术期给予 N-乙酰半胱氨酸，对照组（37 例）未给予。采用独立样本 t 检验（Student's t 检验）和 χ 检验对获得的数据进行分析。
两组肾功能障碍的发生率无显著差异。N-乙酰半胱氨酸组 3 例（8.6%）和对照组 4 例（11.4%）发生肾功能障碍（P 值为 1.00）。
N-乙酰半胱氨酸对高危行不停跳冠状动脉旁路移植术患者的肾功能无有益作用。
