Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, 210038, People's Republic of China.
Biomed Microdevices. 2010 Aug;12(4):655-63. doi: 10.1007/s10544-010-9418-1.
The use of ceramic nano-carriers containing anti-cancer drugs for targeted delivery that span both fundamental and applied research has attracted the interest of the scientific community. In this paper, a hydrophobic photodynamic therapy drug, hypocrellin A (HA), was successfully encapsulated in water-soluble amorphous silica nanocage (HANC) by an improved sol-gel method. These nanocages are of ultrasmall size, highly monodispersed, stable in aqueous suspension, and retain the optical properties of HA. Moreover, these nanocages can be effectively delivered, subsequently taken up by cancer cells and finally targeted to mitochondria. In addition, incubation time dependent photodynamic efficacy difference between HANC and HA was investigated for the first time. Especially, the nanocages, owning extremely high stable fluorescence comparing with free HA, also have potentials as efficient probes for optical biodiagnose in vitro. All these properties of HANC could possibly make it especially promising to be used as a bimodal reagent for photodynamic therapy and biodiagnose.
载有抗癌药物的陶瓷纳米载体用于靶向递释，跨越了基础研究和应用研究，引起了科学界的兴趣。在本文中，通过改进的溶胶-凝胶法，成功地将疏水性光动力治疗药物竹红菌素 A（HA）封装在水溶性无定形硅纳米笼（HANC）中。这些纳米笼具有超小尺寸、高度单分散性、在水悬浮液中稳定，并且保留了 HA 的光学性质。此外，这些纳米笼可以有效地递送至癌细胞，并最终靶向线粒体。此外，首次研究了 HANC 和 HA 之间的孵育时间依赖性光动力功效差异。特别是，纳米笼与游离 HA 相比具有极高的稳定荧光，也有可能成为体外光学生物诊断的有效探针。HANC 的所有这些特性都可能使其特别有希望用作光动力治疗和生物诊断的双模态试剂。
