Jiangsu Key Laboratory Biofunctional Materials, Nanjing Normal University, Nanjing 210097, China.
Int J Pharm. 2010 Feb 15;386(1-2):131-7. doi: 10.1016/j.ijpharm.2009.11.010. Epub 2009 Nov 14.
We report a facile silica nanovehicle preparation procedure for hydrophobic drug delivery, which is carried out in water without adding any surfactant and additional catalyst. This strategy includes hydrophobic drug nanopaticle preparation by reprecipitation method and in situ hydrolyzation and polymerization to encapsulate this naoparticle using only N-(beta-amimoethyl)-gamma-aminopropyltriethoxysilane (AETPS). To demonstrate this technique hypocrellin A (HA), a hydrophobic photosensitizing anticancer drug, is embedded into silica nanovehicle using this simple method. The resulting HA encapsulated nanovehicles (HANV) are monodisperse and stable in aqueous solution. Comparative studies with free HA and entrapped HA have demonstrated that the encapsulation effect on the embedded photosensitizer nanoparticle significantly enhances the efficacy of singlet oxygen generation and, thereby, the in vitro photodynamic efficacy.
我们报告了一种用于疏水性药物传递的简便二氧化硅纳米载体制备方法，该方法在水中进行，无需添加任何表面活性剂和额外的催化剂。该策略包括通过再沉淀法制备疏水性药物纳米颗粒，以及使用仅 N-(β-氨乙基)-γ-氨丙基三甲氧基硅烷 (AETPS) 原位水解和聚合来封装该纳米颗粒。为了证明这种技术，将一种疏水性光动力抗癌药物竹红菌素 A (HA) 嵌入到使用这种简单方法制备的二氧化硅纳米载体中。所得的 HA 包封的纳米载体 (HANV) 在水溶液中呈单分散且稳定。与游离 HA 和包埋 HA 的比较研究表明，对嵌入的光敏剂纳米颗粒的包封效果显著增强了单线态氧生成的功效，从而增强了体外光动力功效。
