以氧化石墨烯作为药物递送系统的化疗与光动力疗法联合应用

Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system.

作者信息

Zhou Lin, Zhou Lin, Wei Shaohua, Ge Xuefeng, Zhou Jiahong, Jiang Huijun, Li Fuyou, Shen Jian

机构信息

College of Chemistry and Materials Science, Analysis and Testing Center, Jiangsu Key Laboratory Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.

School of Chemistry & Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.

出版信息

J Photochem Photobiol B. 2014 Jun 5;135:7-16. doi: 10.1016/j.jphotobiol.2014.04.010. Epub 2014 Apr 24.

DOI:10.1016/j.jphotobiol.2014.04.010

PMID:24792568

Abstract

Previous research indicated that graphene oxide (GO) can be used to deliver photosensitive anticancer drug, Hypocrellin A (HA), in photodynamic therapy (PDT). However, the anticancer activity of HA was obviously decreased after been loaded on GO. To solve this problem, a chemotherapy drug, 7-ethyl-10-hydroxycamptothecin (SN-38), was co-loaded on the HA loaded GO (HA/SN-38/GO) as a multimodal carrier for the synergistic combination of PDT and chemotherapy for cancer. In vitro results showed that the combination therapy exhibited a synergistic antiproliferative effect compared with PDT and chemotherapy alone. Therefore, HA/SN-38/GO delivery system has the potential to offer dual therapies for the synergistic combination of PDT and chemotherapy for the treatment of cancer.

摘要

先前的研究表明，氧化石墨烯（GO）可用于在光动力疗法（PDT）中递送光敏抗癌药物竹红菌素A（HA）。然而，HA负载到GO上后其抗癌活性明显降低。为了解决这个问题，一种化疗药物7-乙基-10-羟基喜树碱（SN-38）被共负载到负载HA的GO（HA/SN-38/GO）上，作为一种多模态载体用于癌症的PDT和化疗的协同联合治疗。体外结果表明，与单独的PDT和化疗相比，联合治疗表现出协同抗增殖作用。因此，HA/SN-38/GO递送系统有潜力为癌症治疗提供PDT和化疗协同联合的双重疗法。