溶葡球菌素基因（lytA）中存在局部噬菌体-宿主重组的证据，该基因编码主要的肺炎链球菌自溶素。
Evidence of localized prophage-host recombination in the lytA gene, encoding the major pneumococcal autolysin.
机构信息
Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu, 9, 28040 Madrid, Spain.
出版信息
J Bacteriol. 2010 May;192(10):2624-32. doi: 10.1128/JB.01501-09. Epub 2010 Mar 19.
Abstract
According to a highly polymorphic region in the lytA gene, encoding the major autolysin of Streptococcus pneumoniae, two different families of alleles can be differentiated by PCR and restriction digestion. Here, we provide evidence that this polymorphic region arose from recombination events with homologous genes of pneumococcal temperate phages.
摘要
根据编码肺炎链球菌主要自溶素的 lytA 基因中的一个高度多态性区域，通过 PCR 和限制性消化可以区分出两种不同的等位基因家族。在这里，我们提供的证据表明，这个多态性区域是由与肺炎球菌温和噬菌体同源基因的重组事件产生的。
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