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IDH1 and IDH2 mutations in gliomas and the associated induction of hypoxia-inducible factor and production of 2-hydroxyglutarate.

作者信息

Komotar Ricardo J, Starke Robert M, Sisti Michael B, Connolly E Sander

出版信息

Neurosurgery. 2010 Apr;66(4):N20-1. doi: 10.1227/01.neu.0000369899.41915.67.

DOI:10.1227/01.neu.0000369899.41915.67
PMID:20305482
Abstract
摘要

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1
IDH1 and IDH2 mutations in gliomas and the associated induction of hypoxia-inducible factor and production of 2-hydroxyglutarate.胶质瘤中的异柠檬酸脱氢酶1(IDH1)和异柠檬酸脱氢酶2(IDH2)突变以及缺氧诱导因子的相关诱导和2-羟基戊二酸的产生。
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2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.由胶质瘤衍生的 NADP 依赖性异柠檬酸脱氢酶突变赋予 2-羟戊二酸的产生,但不是显性负功能。
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Isocitrate dehydrogenase mutations in gliomas.胶质瘤中的异柠檬酸脱氢酶突变
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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.代谢物 2-羟基戊二酸是 α-酮戊二酸依赖性双加氧酶的竞争性抑制剂。
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D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma.D-2-羟戊二酸产生的新酶活性与胶质瘤中发现的异柠檬酸脱氢酶 1 突变类型的频率呈负相关。
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Production of 2-hydroxyglutarate by isocitrate dehydrogenase 1-mutated gliomas: an evolutionary alternative to the Warburg shift?异柠檬酸脱氢酶1突变型胶质瘤产生2-羟基戊二酸:瓦伯格效应转变的一种进化替代方式?
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Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy.使用磁共振波谱技术无创检测 IDH1 突变型脑胶质瘤患者的 2-羟戊二酸和其他代谢物。
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2-Hydroxyglutarate Metabolism Is Altered in an Model of LPS Induced Endotoxemia.
在脂多糖诱导的内毒素血症模型中,2-羟基戊二酸代谢发生改变。
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