Groneck P
Städtisches Kinderkrankenhaus Köln.
Monatsschr Kinderheilkd. 1991 Jan;139(1):33-8.
Serial pulmonary function tests were performed in 13 preterm infants with severe RDS and 16 premature neonates with healthy lungs (8 intubated because of hypovention after birth, 8 were breathing spontaneously). Airflow was measured by a pneumotachograph, pressure changes were determined by airway pressure in ventilated infants or esophageal pressure in spontaneously breathing neonates. Pulmonary mechanics were calculated by a computerized system (PEDS/Medical Associated Services, Hatfield, Pennsylvania). In mechanically ventilated infants with RDS dynamic compliance of the respiratory system was low during the first 6 days. On Day 7-10 there were higher values for infants who could be extubated within the first 10 days compared to those, who had to be ventilated for more than 10 days. In the course of the disease, improvement in gas exchange preceded increase of compliance. Intraindividual comparisons in the acute and recovery phase of RDS and in infants with normal lungs showed higher values for compliance and lower values for airway pressure and resistance during spontaneous breaths. The differences between dynamic compliance of the respiratory system measured during mechanical ventilation, and dynamic lung compliance recorded during spontaneous breaths are due to influences of the respirator on the infant's lung.
对13例患有严重呼吸窘迫综合征（RDS）的早产儿和16例肺部健康的早产儿进行了系列肺功能测试（其中8例因出生后通气不足而插管，8例自主呼吸）。气流通过呼吸流速计测量，压力变化通过通气婴儿的气道压力或自主呼吸新生儿的食管压力来确定。肺力学由计算机系统（PEDS/Medical Associated Services，宾夕法尼亚州哈特菲尔德）计算得出。患有RDS的机械通气婴儿在最初6天内呼吸系统的动态顺应性较低。在第7至10天，与那些必须通气超过10天的婴儿相比，在最初10天内能够拔管的婴儿的顺应性值更高。在疾病过程中，气体交换的改善先于顺应性的增加。对RDS急性和恢复阶段以及肺部正常婴儿的个体内比较显示，自主呼吸时顺应性值更高，气道压力和阻力值更低。机械通气期间测量的呼吸系统动态顺应性与自主呼吸时记录的动态肺顺应性之间的差异是由于呼吸机对婴儿肺部的影响。
