Department of Radiology, Ruhr University Bochum, Universitätsklinikum Bergmannsheil, Buerkle-de-la-Camp-Platz 1, 44789 Bochum, Germany.
AJR Am J Roentgenol. 2010 Apr;194(4):W323-8. doi: 10.2214/AJR.09.2698.
The objective of our study was to identify disease-specific patterns of myopathic changes in patients with lipid-lowering agent (LLA)-associated myopathy using a dedicated MRI protocol.
Axial T1- and T2-weighted STIR images were obtained for the detection of lipomatosis and edema, respectively, of the thighs and legs. Information about patient age, sex, duration of dyslipidemia and of medication use, latency of symptom onset, maximum creatine kinase (CK) level, presence of myalgia and muscle weakness, and LLA or LLAs used was collected.
Significant correlations resulted for the radiologic diagnosis of LLA-associated myopathy and maximum CK level; the presence of edema and maximum CK level; edema and weakness in the ventral thigh muscle group, thigh adductors, or deep dorsal muscle group of the legs; and lipomatosis and weakness of the deep dorsal muscle group of the legs and peroneal muscle group, respectively.
MRI is a method that helps detect active pathologic processes in patients with suspected LLA-associated myopathy but does not reveal disease-specific patterns.
本研究的目的是使用专门的 MRI 方案，确定降脂药物（LLA）相关肌病患者的肌病特异性病变模式。
分别采集大腿和小腿的轴向 T1 加权和 T2 加权短反转恢复（STIR）图像，以检测脂肪增多和水肿。收集患者的年龄、性别、血脂异常和药物使用持续时间、症状出现潜伏期、肌酸激酶（CK）最大值、肌痛和肌无力的存在以及使用的 LLA 或 LLA 的信息。
LLA 相关肌病的放射学诊断与 CK 最大值之间、水肿与 CK 最大值之间、大腿腹侧肌肉群、内收肌群或小腿深背肌群的水肿与无力之间、小腿深背肌群和腓肠肌群的脂肪增多与无力之间存在显著相关性。
MRI 是一种有助于检测疑似 LLA 相关肌病患者中活跃病理过程的方法，但不能揭示疾病特异性模式。
