Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA.
Nat Rev Mol Cell Biol. 2010 Apr;11(4):276-87. doi: 10.1038/nrm2866.
Specialized membrane domains are an important feature of almost all cells. In particular, they are essential to tissues that have a highly organized cell cortex, such as the intestinal brush border epithelium. The ERM proteins (ezrin, radixin and moesin) have a crucial role in organizing membrane domains through their ability to interact with transmembrane proteins and the cytoskeleton. In doing so, they can provide structural links to strengthen the cell cortex and regulate the activities of signal transduction pathways. Recent studies examining the structure and in vivo functions of ERMs have greatly advanced our understanding of the importance of membrane-cytoskeleton interactions.
专门的膜域是几乎所有细胞的一个重要特征。特别是对于那些具有高度组织化的细胞皮层的组织，如肠道刷状缘上皮，它们是必不可少的。ERM 蛋白（埃兹蛋白、根蛋白和膜突蛋白）通过与跨膜蛋白和细胞骨架相互作用，在组织膜域方面发挥着关键作用。通过这种方式，它们可以提供结构连接，以加强细胞皮层并调节信号转导途径的活性。最近研究 ERM 的结构和体内功能的研究极大地提高了我们对膜-细胞骨架相互作用重要性的认识。
