Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
Chem Soc Rev. 2010 Apr;39(4):1280-90. doi: 10.1039/b901973c. Epub 2009 Jul 27.
First described almost a decade ago, "click" reactions such as the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) are widely used today in organic and medicinal chemistry, in the polymer and material science field, and in chemical biology. While most click reactions can be performed at room temperature there are instances where some form of process intensification is required. In this tutorial review, aimed at the synthetic chemistry community, examples of click chemistry carried out under non-classical reaction conditions, such as for example applying microwave heating or continuous flow processing will be highlighted.
首次描述于近十年前，“点击”反应（如 CuAAC）如今在有机和药物化学、聚合物和材料科学领域以及化学生物学中得到广泛应用。虽然大多数点击反应可以在室温下进行，但在某些情况下需要某种形式的强化过程。在这个面向合成化学家的综述中，将重点介绍在非典型反应条件下进行的点击化学的例子，例如应用微波加热或连续流动处理。
