Department of Obstetrics and Gynecology, Democritus University of Thrace, Alexandroupolis, Greece.
Arch Gynecol Obstet. 2010 Aug;282(2):215-9. doi: 10.1007/s00404-010-1425-1. Epub 2010 Mar 23.
To investigate the effect of age and smoking on the AMH levels in normal cycling healthy women with normal reproductive history.
In 137 women, blood samples were taken on day 3 of a spontaneous cycle. Serum FSH, LH, E2, progesterone and AMH were measured in all blood samples. For the statistical analysis of the data, t test, Pearson's correlation and linear regression analysis were performed.
Of 137 women (43%), 59 were smokers. Age was positively correlated with serum FSH and LH levels (r = 0.584, P < 0.001 and r = 0.330, P < 0.001, respectively) and negatively correlated with serum AMH levels (r = -0.882, P < 0.001). There were no significant differences in FSH, LH, E2, progesterone and AMH levels between smokers and non-smokers. Multiple stepwise linear regression analysis showed that in both smokers and non-smokers, age was the most significant determinant of AMH levels (r = -0.889, P < 0.001 and r = -0.944, P < 0.001, respectively), while smoking was not related to AMH levels.
Aging significantly decreases AMH levels in women with normal cycles and normal reproductive history, while smoking does not seem to have significant effects on AMH levels.
研究年龄和吸烟对有正常生殖史的正常排卵健康女性的 AMH 水平的影响。
在 137 名女性中，在自然周期的第 3 天采集血样。所有血液样本均测量血清 FSH、LH、E2、孕酮和 AMH。为了对数据进行统计分析，进行了 t 检验、Pearson 相关性和线性回归分析。
137 名女性中（43%）有 59 名吸烟者。年龄与血清 FSH 和 LH 水平呈正相关（r = 0.584，P < 0.001 和 r = 0.330，P < 0.001），与血清 AMH 水平呈负相关（r = -0.882，P < 0.001）。吸烟者和非吸烟者之间的 FSH、LH、E2、孕酮和 AMH 水平无显著差异。多元逐步线性回归分析表明，在吸烟者和非吸烟者中，年龄是 AMH 水平的最显著决定因素（r = -0.889，P < 0.001 和 r = -0.944，P < 0.001），而吸烟与 AMH 水平无关。
在有正常周期和正常生殖史的女性中，衰老会显著降低 AMH 水平，而吸烟似乎对 AMH 水平没有显著影响。
