Department of Neurological Sciences, University of Rome Sapienza, Rome, Italy.
Mov Disord. 2010 Jul 15;25(9):1203-9. doi: 10.1002/mds.23093.
In Parkinson's disease (PD) the urinary dysfunction manifests primarily with symptoms of overactive bladder (OAB). The OAB questionnaire (OAB-q) is a measure designed to assess the impact of OAB symptoms on health-related quality of life. In this study, we quantified the urinary symptoms in a large cohort of PD patients by using the OAB-q short form. Possible correlations between the OAB-q and clinical features were tested. Three hundred and two PD patients were enrolled in the study. Correlations between the OAB-q and sex, age, Unified Parkinson's Disease Rating Scale part III (UPDRS-III), Hoehn-Yahr (H-Y) staging, disease duration, and treatment were analyzed. Data were compared with a large cohort of 303 age-matched healthy subjects. The OAB-q yielded significantly higher scores in PD patients than in healthy subjects. In the group of PD patients, all the variables tested were similar between men and women. Pearson's coefficient showed a significant correlation between mean age, disease duration, mean OAB-q scores, UPDRS-III scores, and H-Y staging. A multiple linear regression analysis showed that OAB-q values were significantly influenced by age and UPDRS-III. No statistical correlations were found between OAB-q scores and drug therapy or the equivalent levodopa dose, whilst the items relating to the nocturia symptoms were significantly associated with the equivalent levodopa dose. Our findings suggest that bladder dysfunction assessed by OAB-q mainly correlates with UPDRS-III scores for severity of motor impairment, possibly reflecting the known role of the decline in nigrostriatal dopaminergic function in bladder dysfunction associated with PD and patients' age. Our study also suggests that the OAB-q is a simple, easily administered test that can objectively evaluate bladder function in patients with PD.
在帕金森病（PD）中，尿功能障碍主要表现为膀胱过度活动症（OAB）的症状。OAB 问卷（OAB-q）是一种旨在评估 OAB 症状对健康相关生活质量影响的测量方法。在这项研究中，我们使用 OAB-q 短表来量化大量 PD 患者的尿症状。测试了 OAB-q 与临床特征之间的可能相关性。研究共纳入 302 名 PD 患者。分析了 OAB-q 与性别、年龄、统一帕金森病评定量表第三部分（UPDRS-III）、Hoehn-Yahr（H-Y）分期、疾病持续时间和治疗之间的相关性。将数据与 303 名年龄匹配的健康受试者的大队列进行比较。与健康受试者相比，PD 患者的 OAB-q 评分显著更高。在 PD 患者组中，所有测试变量在男性和女性之间均相似。Pearson 系数显示平均年龄、疾病持续时间、平均 OAB-q 评分、UPDRS-III 评分和 H-Y 分期之间存在显著相关性。多元线性回归分析显示，OAB-q 值受年龄和 UPDRS-III 的显著影响。OAB-q 评分与药物治疗或等效左旋多巴剂量之间未发现统计学相关性，而与夜尿症症状相关的项目与等效左旋多巴剂量显著相关。我们的研究结果表明，OAB-q 评估的膀胱功能主要与 UPDRS-III 评估的运动障碍严重程度相关，这可能反映了中脑黑质多巴胺能功能下降在与 PD 相关的膀胱功能障碍和患者年龄中的已知作用。我们的研究还表明，OAB-q 是一种简单、易于管理的测试方法，可以客观地评估 PD 患者的膀胱功能。
