Matza Louis S, Thompson Christine L, Krasnow Joel, Brewster-Jordan Jessica, Zyczynski Teresa, Coyne Karin S
MEDTAP International, Inc., Bethesda, Maryland 20814, USA.
Neurourol Urodyn. 2005;24(3):215-25. doi: 10.1002/nau.20110.
This study examined test-retest reliability of four patient-reported outcome measures for patients with overactive bladder (OAB): Overactive Bladder Questionnaire (OAB-q), Patient Perception of Bladder Condition (PPBC), Urgency Questionnaire (UQ), and Primary OAB Symptom Questionnaire (POSQ).
Patients recruited from urology clinics were scheduled for two visits 2 weeks apart and completed all questionnaires at both visits. A demographic form was completed at Visit 1; and a treatment effect scale was completed at Visit 2. Test-retest reliability was examined among stable patients using intraclass correlations (ICC), Spearman's correlations, paired t-tests, Feldt's statistic, and kappas.
A total of 47 patients enrolled (mean age = 66.0 years, 74.5% female), with 46 completing both visits; 35 were classified stable. Statistically significant correlations were present between Visits 1 and 2 (P < 0.05) for all subscales of the OAB-q, UQ, and POSQ. Subscale ICCs were moderate to high (OAB-q > or = 0.83, UQ > or = 0.46, POSQ continuous items > or = 0.68). No significant differences between Visit 1 and 2 were noted, except for the OAB-q symptom bother scale (change of 5.8 points on a 100-point scale). The multi-item subscales of the OAB-q and the UQ demonstrated good internal consistency (Cronbach's alpha > or = 0.83 for all subscales) across both visits. Test-retest reliability of the PPBC was somewhat weaker than the other three measures, but still acceptable for use as a global, single-item outcome measure.
The OAB-q, POSQ, and UQ demonstrated good test-retest reliability, with ICCs roughly equivalent or superior to those previously reported for 7-day micturition diaries. Findings suggest that the four measures examined in this study demonstrate the necessary reproducibility for use as outcome measures for OAB treatments.
本研究考察了膀胱过度活动症（OAB）患者的四种患者报告结局指标的重测信度，这四种指标分别为：膀胱过度活动症问卷（OAB-q）、患者对膀胱状况的感知（PPBC）、尿急问卷（UQ）以及主要OAB症状问卷（POSQ）。
从泌尿外科诊所招募患者，安排他们在相隔2周的时间进行两次就诊，并在两次就诊时完成所有问卷。在第一次就诊时填写一份人口统计学表格；在第二次就诊时填写一份治疗效果量表。使用组内相关系数（ICC）、Spearman相关系数、配对t检验、Feldt统计量和kappa系数对病情稳定的患者进行重测信度检验。
共纳入47例患者（平均年龄 = 66.0岁，74.5%为女性），其中46例完成了两次就诊；35例被归类为病情稳定。OAB-q、UQ和POSQ的所有子量表在第一次和第二次就诊之间均存在统计学显著相关性（P < 0.05）。子量表的ICC为中度至高度（OAB-q≥0.83，UQ≥0.46，POSQ连续项目≥0.68）。除了OAB-q症状困扰量表（在100分制上变化了5.8分）外，第一次和第二次就诊之间未发现显著差异。OAB-q和UQ的多项目子量表在两次就诊中均表现出良好的内部一致性（所有子量表的Cronbach's α≥0.83）。PPBC的重测信度略低于其他三项指标，但作为一项整体的单项结局指标仍可接受。
OAB-q、POSQ和UQ表现出良好的重测信度，其ICC大致等同于或优于先前报道的7天排尿日记的ICC。研究结果表明，本研究中考察的这四项指标具有用作OAB治疗结局指标所需的可重复性。
