酵母中的前体信使核糖核酸剪接
Pre-mRNA splicing in yeast.
作者信息
Ruby S W, Abelson J
机构信息
Division of Biology, California Institute of Technology, Pasadena 91125.
出版信息
Trends Genet. 1991 Mar;7(3):79-85. doi: 10.1016/0168-9525(91)90276-V.
PMID:2031287
Abstract
Splicing of introns from nuclear precursor messenger RNAs (pre-mRNAs) occurs in all eukaryotes. Two aspects of the splicing mechanism need to be understood: how intron sequences are recognized and aligned and how splicing is catalysed. Recent genetic and biochemical studies in the simple eukaryote Saccharomyces cerevisiae are revealing some of the features of the splicing mechanism.
摘要
从核内前体信使核糖核酸（前体mRNA）中剪接内含子的过程在所有真核生物中都会发生。剪接机制有两个方面需要弄清楚：内含子序列是如何被识别和比对的，以及剪接是如何被催化的。近期在简单真核生物酿酒酵母中开展的遗传学和生物化学研究正在揭示剪接机制的一些特征。
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