Haglid K G, Hamberger A, Carlsson C A, Lindgren S, Stavrou D, Sourander P
Acta Neuropathol. 1977 Nov 28;40(3):243-7. doi: 10.1007/BF00691961.
The heterogeneity of brain tumours, especially in the glioblastoma group, makes biochemical characterization of pieces of the tumours hazardous even with extensive histological controls. This study employs a technique by which separate cell populations are subsequently isolated from the tumours by means of density gradient centrifugation. Cells isolated from glial brain tumours with low density sedimentation rates show the highest levels of glial cell characteristics, i.e. S-100 content and active uptake of the neurotransmitter GABA.
脑肿瘤的异质性，尤其是胶质母细胞瘤组，使得即使有广泛的组织学对照，对肿瘤组织块进行生化特征分析也具有风险。本研究采用了一种技术，通过密度梯度离心从肿瘤中分离出不同的细胞群体。从胶质脑肿瘤中分离出的低密度沉降率细胞显示出最高水平的胶质细胞特征，即S-100含量和神经递质GABA的主动摄取。
