Tajima N, Uematsu M, Asukata I, Yamamoto K, Sasaki M, Hokari M
Flight Crew Medical Service Department, Japan Airlines, Tokyo.
Aviat Space Environ Med. 1991 Apr;62(4):325-7.
The objective of the present study is to investigate the change in the circadian rhythm of plasma cortisol levels following a 3-d trip and a westbound return flight from San Francisco (SFO) to Tokyo. Six healthy male students volunteered for the project. Plasma cortisol levels were monitored 4 times daily for 13 d during the experimental period. In Tokyo, the baseline pattern of cortisol concentrations showed the classical diurnal profile. During the 50-h stay in SFO, phase advancement of 8 h was observed for the initial 32 h. This was followed by a disturbance in the profile for the remaining 18-h period. After returning to Tokyo, the subjects exhibited the original diurnal pattern beginning Day 1. However, complete resynchronization was not apparent until Day 4 after the return.
本研究的目的是调查一次为期3天的旅行以及从旧金山（SFO）到东京的向西返程航班后血浆皮质醇水平昼夜节律的变化。六名健康男学生自愿参与该项目。在实验期间，每天监测血浆皮质醇水平4次，持续13天。在东京，皮质醇浓度的基线模式呈现出典型的昼夜分布。在旧金山停留的50小时内，最初32小时观察到相位提前8小时。随后在剩余的18小时内分布出现紊乱。回到东京后，受试者从第1天开始呈现出原来的昼夜模式。然而，直到返回后第4天才明显完全重新同步。
