Chiddo A, Gaglione A, Musci S, Troito G, Grimaldi N, Locuratolo N, Rizzon P
Division of Cardiology, University of Bari, Italy.
Cardiovasc Drugs Ther. 1991 Feb;5 Suppl 1:107-11. doi: 10.1007/BF00128249.
Propionyl-L-carnitine was given intravenously to ten patients with chronic ischemic heart disease who had normal left ventricular function and had not had a previous myocardial infarction. Subsequently, pulmonary and systemic circulation, left ventricular function, and the relationship between the ventricle and afterload were evaluated. This drug, at a dose of 15 mg/kg, improves ventricular function by easing the load and by enhancing cardiac efficiency. The ejection impedance is reduced with a consequent increase in stroke volume as a result of a) a decrease in systemic and pulmonary resistance and b) an increase in arterial compliance. Arterial pressure is maintained due to an increase in total external heart power. Since the tension time index shows a proportionally smaller increase in the energy requirement, it follows that cardiac efficiency has been improved and ventricle-afterload matching is optimal. These results suggest but do not prove that propionyl-L-carnitine exhibits a positive inotropic property.
对十名左心室功能正常且既往无心肌梗死的慢性缺血性心脏病患者静脉注射丙酰-L-肉碱。随后，评估肺循环和体循环、左心室功能以及心室与后负荷之间的关系。该药物以15mg/kg的剂量给药，通过减轻负荷和提高心脏效率来改善心室功能。射血阻抗降低，由于以下原因导致每搏量增加：a）体循环和肺循环阻力降低；b）动脉顺应性增加。由于心脏总外部功率增加，动脉压得以维持。由于张力时间指数显示能量需求增加的比例较小，因此心脏效率得到改善，心室-后负荷匹配最佳。这些结果表明但未证明丙酰-L-肉碱具有正性肌力作用。
