Muscat J E, Huncharek M S
American Health Foundation, New York, NY 10017.
Cancer Detect Prev. 1991;15(2):155-9.
A population-based, case-control study was conducted to examine whether infrequent breast self-examination (BSE) is associated with the detection of breast cancer at a later stage of disease. A group of 435 women with newly diagnosed, regional or distant breast carcinoma from Connecticut were interviewed and compared with 887 age-frequency-matched women without breast cancer. A case-control method eliminates lead time bias that may have been present in prior studies that evaluated BSE efficacy. Cases were found to have practiced monthly BSE more frequently than controls (27 vs. 21%). No differences in frequency of BSE was found between cases and controls after controlling for the potentially confounding effects of breast cancer risk factors and mammography (OR = 1.26; 95% CI, 0.77 to 2.07).
开展了一项基于人群的病例对照研究，以检验不常进行乳房自我检查（BSE）是否与乳腺癌在疾病晚期的发现有关。对来自康涅狄格州的435名新诊断为局部或远处乳腺癌的女性进行了访谈，并与887名年龄频率匹配的无乳腺癌女性进行了比较。病例对照方法消除了先前评估BSE功效的研究中可能存在的领先时间偏倚。发现病例组每月进行BSE的频率高于对照组（27%对21%）。在控制了乳腺癌风险因素和乳房X线摄影的潜在混杂效应后，病例组和对照组在BSE频率上未发现差异（优势比=1.26；95%可信区间，0.77至2.07）。
