University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh, India.
Br J Dermatol. 2010 Aug;163(2):412-5. doi: 10.1111/j.1365-2133.2010.09772.x. Epub 2010 Mar 17.
For several decades, androgens have dominated endocrine research in the domain of hair growth control. However, it has long been known that oestrogens also tend to alter hair follicle (HF) growth and cycling significantly by binding to locally expressed high-affinity oestrogen receptors (ORs). Tamoxifen (TAM) is a selective OR modulator.
The current work aims to investigate the effect of topically applied TAM on the hair growth of mice.
Test formulations were applied once daily on the shaved back area of the mice for a period of 5 weeks. The effect of these formulations was studied by visual and histological examinations.
Animals treated with saline and placebo gel formulation showed significant hair growth on the 20th day. The number and length of follicles were also found to be normal. In contrast, no hair growth was observed in the animals treated with TAM gel, even after the termination of treatment. The HFs were found to be arrested in telogen phase with clear signs of follicle dystrophy.
The hair growth-retarding effect of TAM observed in the current study clearly demonstrates its OR agonistic effect on hair growth. This work also provides a distinct lead towards the possible potential of TAM liposomal gel in the treatment of hirsutism.
几十年来，雄激素一直主导着毛发控制领域的内分泌研究。然而，人们早就知道雌激素也通过与局部表达的高亲和力雌激素受体（OR）结合，显著改变毛囊（HF）的生长和周期。他莫昔芬（TAM）是一种选择性 OR 调节剂。
本研究旨在探讨局部应用 TAM 对小鼠毛发生长的影响。
测试制剂每天一次应用于剃毛后的小鼠背部区域，持续 5 周。通过视觉和组织学检查研究这些制剂的效果。
用生理盐水和安慰剂凝胶制剂处理的动物在第 20 天表现出明显的毛发生长。还发现毛囊的数量和长度正常。相比之下，用 TAM 凝胶处理的动物在治疗结束后甚至没有观察到毛发生长。HF 被发现处于休止期，有明显的毛囊发育不良迹象。
本研究中观察到 TAM 的毛发生长抑制作用清楚地表明其对毛发生长的 OR 激动作用。这项工作还为 TAM 脂质体凝胶在治疗多毛症方面的潜在可能性提供了明确的依据。
