阿尔茨海默病的 T(1ρ) MRI：检测内侧颞叶的病变。
T(1ρ) MRI in Alzheimer's disease: detection of pathological changes in medial temporal lobe.
机构信息
CMROI, SBIA, Center for Neurodegenerative Disease Research, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104-6100, USA.
出版信息
J Neuroimaging. 2011 Apr;21(2):e86-90. doi: 10.1111/j.1552-6569.2010.00467.x.
BACKGROUND
The need of an early and noninvasive diagnosis of AD requires the development of imaging-based techniques. As an alternative, the magnetic resonance image (MRI) relaxation time constant (T1ρ) was measured in brains of Alzheimer's disease (AD), mild-cognitive impairment (MCI), and age-matched controls in order to determine whether T1ρ values correlated with the neurological diagnosis.
METHODS
MRI was performed on AD (n=48), MCI (n=45), and age-matched control (n=41), on a 1.5 Tesla Siemens clinical MRI scanner. T1ρ maps were generated by fitting each pixel's intensity as a function of the duration of the spin-lock pulse. T1ρ values were calculated from the gray matter (GM) and white matter (WM) of medial temporal lobe (MTL).
RESULTS
GM and WM T1ρ values were 87.5±1.2 ms and 80.5±1.4 ms, respectively, in controls, 90.9±1.3 ms and 84.1±1.7 ms in MCI, and 91.9±.8 ms and 88.3±1.3 ms in AD cohorts. Compared to control, AD patients showed 9% increased WM T1ρ and 5% increased GM T1ρ. Compared to control, MCI individuals showed 4% increased T1ρ both in WM and GM. A 5% increased T1ρ was found in WM of AD over MCI.
CONCLUSION
The increased T1ρ in WM and GM of MTL in AD may be associated with the pathological changes that are not evident on conventional MRI.
背景
需要早期和非侵入性的 AD 诊断，这就需要开发基于成像的技术。作为替代方法，在阿尔茨海默病（AD）、轻度认知障碍（MCI）和年龄匹配的对照组的大脑中测量磁共振图像（MRI）弛豫时间常数（T1ρ），以确定 T1ρ 值是否与神经诊断相关。
方法
在 1.5T 西门子临床 MRI 扫描仪上对 AD（n=48）、MCI（n=45）和年龄匹配的对照组（n=41）进行 MRI 检查。通过拟合每个像素的强度作为自旋锁定脉冲持续时间的函数来生成 T1ρ 图。从内侧颞叶（MTL）的灰质（GM）和白质（WM）计算 T1ρ 值。
结果
对照组 GM 和 WM 的 T1ρ 值分别为 87.5±1.2ms 和 80.5±1.4ms，MCI 组分别为 90.9±1.3ms 和 84.1±1.7ms，AD 组分别为 91.9±0.8ms 和 88.3±1.3ms。与对照组相比，AD 患者的 WM T1ρ 增加 9%，GM T1ρ 增加 5%。与对照组相比，MCI 个体的 WM 和 GM 中的 T1ρ 均增加了 4%。AD 患者 WM 中的 T1ρ 比 MCI 患者增加了 5%。
结论
AD 患者 MTL 的 WM 和 GM 中的 T1ρ 增加可能与常规 MRI 上未显示的病理变化有关。
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